3例酮咯酸氨丁三醇严重不良反应分析并防范措施和处置原则讨论  

Analysis of 3 cases of Serious Adverse Reactions of Ketorolac Tromethamine and Discussion of Preventive Measures and Treatment Principles

作　　者：邬丽玲 李晓红 刘建芳[1] 徐丽[1] 许巧霞 WU Liling;LI Xiaohong;LIU Jianfang;XU Li;XU Qiaoxia(Department of Pharmacy,Rizhao People’s Hospital,Rizhao of Shandong 276826;McGaid County People’s Hospital,Kashgar,Xinjiang 844660)

机构地区：[1]日照市人民医院药学部,山东日照276826 [2]麦盖提县人民医院,新疆喀什844660

出　　处：《中国药物滥用防治杂志》2022年第9期1208-1212,共5页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:探讨酮咯酸氨丁三醇发生严重不良反应的风险点,以期降低不良反应及病情恶化的发生率。方法:对日照市人民医院2020年6月—2021年12月上报的酮咯酸氨丁三醇注射液发生的严重不良反应进行病例分析,提取风险信号。结果:酮咯酸氨丁三醇注射液发生严重不良反应的风险点有超疗程给药;眼睑水肿、过敏反应等处理不及时会引起病情恶化。结论:临床应严格按小于5天的疗程使用酮咯酸氨丁三醇注射液;一旦出现眼睑水肿、过敏反应等应及时用糖皮质激素类及抗组胺药物处理,以降低该药严重不良反应及病情恶化的发生率。Objective:To investigate the risk points of serious adverse reactions of ketorolac tromethamine in order to reduce the incidence of adverse reactions and disease progression.Methods:The serious adverse reactions of ketorolac tromethamine injection reported in Rizhao People’s Hospital from June 2020 to December 2021 were analyzed,and the risk signals were extracted.Results:The risk of serious adverse reactions of ketorolac tromethamine injection was over-treatment.Eyelid edema,allergic reaction and other treatment was not timely will cause disease deterioration.Conclusion:Ketorolac ambutritol injection should be used strictly according to the treatment course of less than 5 days.In case of eyelid edema and allergic reaction,glucocorticoids and antihistamines should be used in time to reduce the incidence of serious adverse reactions and deterioration of the condition.

关 键 词：酮咯酸氨丁三醇 严重不良反应 风险点 风险点防范措施 处置原则 

分 类 号：R969.3[医药卫生—药理学]