外泌体在针刺穴区物理信息向化学信息转化中的作用探讨  

Discussion on the role of exosomes in the transformation from physical information to chemical information in acupuncture point area

作　　者：李柠岑 吕中茜[1,2,4] 陈泽林 杨克俭[1,2] 张靖宇 王美娟 公一囡 陈勇 单凯 郭义 陈波 LI Ning-cen;LYU Zhong-xi;CHEN Ze-lin;YANG Ke-jian;ZHANG Jing-yu;WANG Mei-juan;GONG Yi-nan;CHEN Yong;SHAN Kai;GUO Yi;CHEN Bo(Research Center of Experimental Acupuncture Science,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;School of Acupuncture&Moxibustion and Tuina,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Nanfang Hospital,Southerm Medical University,Guangzhou 510515,China;National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300381,China;School of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津中医药大学实验针灸学研究中心,天津301617 [2]天津中医药大学针灸推拿学院,天津301617 [3]南方医科大学南方医院,广州510515 [4]国家中医针灸临床医学研究中心,天津300381 [5]天津中医药大学中医学院,天津301617

出　　处：《中华中医药杂志》2022年第10期6087-6090,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：中国科协青年人才托举工程项目(No.2019-2021ZGZJXH-QNRC001);国家自然科学基金项目(No.82030125,No.82004467,No.82105023);天津中医药大学研究生创新项目(No.YJSKC-20201039);天津市研究生科研创新项目(No.2019YJSB139)。

摘　　要：穴位作为针刺效应的共有源头环节,具有普适性作用机制,在针刺信息的启动过程中发挥重要作用,涉及多个环节和众多物质。但作为一种非特异性外界物理刺激,除生物化学机制外,针刺效应的启动还应存在生物物理过程。本课题组最新研究发现,外泌体运载物中包含神经递质、激素、细胞因子等各种信号分子,作为神经、内分泌、免疫等细胞间相互通讯的重要载体,可能在针刺信息传递过程中发挥重要作用,结合外泌体特性,推测穴区外泌体是针刺物理信息向化学信息转换的重要交互形式。针刺刺激穴位后,局部纤维组织缠绕、断裂、细胞损伤,损伤相关因子释放,激活相应细胞,释放外泌体,激活穴位初始动力学小网络,使针刺信息在穴位局部级联放大,产生“小刺激,大反应”的针刺瀑布式效应。As the common source of acupuncture effect, acupoints have universal mechanism and play an important role in the initiation of acupuncture information, involving many links and substances. However, as a non-specific external physical stimulation, besides biochemical mechanism, there should be biophysical process in the initiation of acupuncture effect. The latest research in our laboratory has found that exosomes contain various signal molecules, such as neurotransmitters, hormones,cytokines and so on. As an important carrier of communication among neuro, endocrine and immune cells, it may play an important role in the transmission of acupuncture information. According to the characteristics of exosomes, it is speculated that the exosomes in the acupoint area are an important interactive form for the transformation of acupuncture physical information to chemical information. After acupuncture stimulation of acupoints, local fibrous tissue twines, breaks, and cells are damaged.The factors related to injury are released. The corresponding cells are activated, exosomes are released, and the initial dynamic small network of acupoints is activated. The acupuncture information is cascaded and amplified in local acupoints, resulting in the acupuncture waterfall effect of ’small stimulation, large response’.

关 键 词：针刺 启动 物理信息 化学信息 外泌体 

分 类 号：R245[医药卫生—针灸推拿学]