Real world analysis on renal impairment of elemene emulsion injection based on propensity score matching  

作　　者：LEI Chao ZHAO Xiao-xiao YU Xiao-kang XIE Yan-ming WANG Zhi-fei 

机构地区：[1]Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China [2]School of Statistics,Renmin University,Beijing 100872,China

出　　处：《Journal of Hainan Medical University》2022年第18期33-37,共5页海南医学院学报（英文版）

基　　金：Key project of Science and Technology Innovation Project of China Academy of Chinese Medical Sciences(NO.CI2021A00702);the National Key Research and Development Program(NO.2018YFC1707410)。

摘　　要：Objective:To explore the main factors of renal function injury caused by the combination of elemene emulsion injection in the real world.Methods:Based on the hospital information system medical database constructed by the Institute of Clinical Basic Medicine of Chinese Academy of Traditional Chinese Medicine,taking the patient information of elemene emulsion injection used in 21 top three hospitals in China as the research object,the nested case control study method was used to compare the combined medication of patients with renal function injury group and control group,The main factors that may lead to renal function injury were screened by MCP variable selection method,and the above main factors were further analyzed by classical logistic regression and propensity score logistic regression method.Results:The analysis found that the combined use of potassium chloride within 7 d before the use of elemene emulsion injection or the combined use of furosemide during the use of elemene emulsion injection may be the main factor leading to renal function injury.Conclusion:The combination of elemene emulsion injection and the above main factors that may lead to renal injury should be avoided.If it must be used,clinical monitoring should be strengthened,and abnormal reactions should be treated immediately.The results of this study have certain clinical significance,and the clinical mechanism can be further studied and explored in the future.

关 键 词：Real world Elemene emulsion injection Renal impairment Propensity score 

分 类 号：R969[医药卫生—药理学]