天津市新型冠状病毒Omicron变异株感染患儿恢复期临床特征分析  

Clinical characteristics of convalescent children infected with SARS-CoV-2 Omicron variant in Tianjin

作　　者：孙雁[1] 王兵[1] 张泽华 张国锋 王雪 王长洁 李丹阳 张景晓 Sun Yan;Wang Bing;Zhang Zehua;Zhang Guofeng;Wang Xue;Wang Changjie;Li Danyang;Zhang Jingxiao(Department of Surgical Intensive Care Unit,Tianjin First Central Hospital,Tianjin 300192,China;Tianjin Key Laboratory of Organ Transplantation,Tianjin 300192,China;Department of Pediatric Transplantation,Tianjin First Central Hospital,Tianjin 300192,China)

机构地区：[1]天津市第一中心医院外科重症监护室,天津300192 [2]天津市器官移植重点实验室,天津300192 [3]天津市第一中心医院儿童器官移植科,天津300192

出　　处：《中华儿科杂志》2022年第10期1054-1058,共5页Chinese Journal of Pediatrics

基　　金：组分中药国家重点实验室(CBCM2022105)。

摘　　要：目的探究天津市新型冠状病毒Omicron变异株感染后处于恢复期患儿的临床特征。方法回顾性分析2022年1月22日至2月24日天津市第一中心医院(天津市新型冠状病毒感染患儿定点救治医院)进行恢复期治疗的104例新型冠状病毒Omicron变异株感染后患儿的临床分型、新型冠状病毒抗体检测、新型冠状病毒核酸检测等临床资料, 根据新型冠状病毒灭活疫苗接种情况将患儿分为接种≥2剂次组和未接种组;根据住院过程中核酸复阳情况将患儿分为复阳组和阴性组, 组间比较采用χ2检验。结果 104例患儿中男53例、女51例, 就诊年龄10.0(0.3, 14.0)岁, 92例(88.5%)为轻型, 12例(11.5%)为普通型。未接种组就诊年龄及新型冠状病毒IgG抗体均低于接种≥2剂次组[2.0(0.3, 10.2)比10.0(3.2, 14.0)岁、10(2, 17)比193(157, 215), χ^(2)=-5.57、Z=-48.76, 均P<0.001]。未接种组家庭聚集性发病占比及新型冠状病毒IgM抗体均高于接种≥2剂次组[13/14比62.2%(56/90)、0.4(0.2, 0.8)比0.4(0.2, 1.1), χ^(2)=5.09、Z=-48.95, 均P<0.05]。复阳组具有基础疾病的患儿占比及新型冠状病毒IgM抗体均高于阴性组[2/13比1.1%(1/91)、0.6(0.2, 1.0)比0.3(0.2, 0.7), χ^(2)=8.29、Z=2.70, 均P<0.05]。复阳组新型冠状病毒IgG抗体低于阴性组[160(78, 197)比213(186, 231), Z=-3.20, P<0.05]。结论天津市新型冠状病毒Omicron变异株感染的患儿多为家庭聚集性发病, 临床分型以轻型为主。新型冠状病毒灭活疫苗接种≥2剂次患儿具有较高的IgG抗体水平及较低的IgM抗体水平。具有基础疾病或新型冠状病毒IgG抗体水平偏低的患儿核酸复阳概率高。Objective To analyze the clinical characteristics of SARS-CoV-2 Omicron variant infected children in convalescence in Tianjin.Methods A total of 104 pediatric patients infected by SARS-CoV-2 Omicron variant Tianjin First Central Hospital(designated hospital for SARS-CoV-2 infection in Tianjin)for convalescent treatment from January 22nd,2022 to February 24th were included for a retrospective study.Clinical data including clinical typing,SARS-CoV-2 IgG and IgM test and 2019-nCoV nucleic acid test were collected.The cases were divided into 2-dose group and zero-dose group based on the doses of inactivated SARS-CoV-2 vaccine.The children were divided into repositive group and negative group,according to the nucleic acid test during hospitalization.Chi-square test was used for the comparison between the groups.Results The age of these 104 children was 10.0(0.3,14.0)years on admission,53 children were males and 51 were females,92 cases(88.5%)had mild symptoms,12 cases(11.5%)had common symptoms.The age and SARS-CoV-2 IgG level of zero-dose group was lower(2.0(0.3,10.2)vs.10.0(3.2,14.0)years,10(2,17)vs.193(157,215),χ^(2)=-5.57,Z=-48.76,both P<0.001)than that of 2-dose group.The zero-dose group had a high rate of transmission among family members and a high level of SARS-CoV-2 IgM level(13/14 vs.62.2%(56/90),0.4(0.2,0.8)vs.0.4(0.2,1.1),χ^(2)=5.09,Z=-48.95,both P<0.05)than the 2-dose group.Repositive group had a high rate of underlying diseases and SARS-CoV-2 IgM level was higher(2/13)vs.1.1%(1/91),(0.6(0.2,1.0)vs.0.3(0.2,0.7),χ^(2)=8.29,Z=2.70,both P<0.05)than negative group.The SARS-CoV-2 IgG level of repositive group was lower than that of negative group(160(78,197)vs.213(186,231),χ^(2)=-3.20,P<0.05).Conclusions Children infected with SARS-CoV-2 Omicron variant in Tianjin were mainly transmitted by family members,and most of them had mild symptoms.Two-dose group had higher IgG levels and lower IgM levels than zero-dose group.The probability of SARS-CoV-2 nucleic acid test repositivity increased in children with und

关 键 词：儿童 新型冠状病毒 Omicron变异株 疫苗 新型冠状病毒抗体 

分 类 号：R725.1[医药卫生—儿科]