加味蛇床子汤与苦参汤治疗湿热下注型肛门湿疹的临床效果比较  

Comparison of Clinical Curative Effect of Modified Shechuangzi Decoction and Kushen Decoction in the Treatment of Damp-heat Type Anal Eczema

作　　者：梁秋萍 谢翔宇[1] 林明惠 LIANG Qiuping;XIE Xiangyu;LIN Minghui(Quanzhou Hospital of Traditional Chinese Medicine,Fujian Province,Quanzhou 362000,China)

机构地区：[1]福建省泉州市中医院,福建泉州362000

出　　处：《中国医学创新》2022年第27期67-71,共5页Medical Innovation of China

摘　　要：目的:对比湿热下注型肛门湿疹患者应用加味蛇床子汤及苦参汤治疗的效果。方法:选取2015年6月-2020年6月泉州市中医院收治的59例湿热下注型肛门湿疹患者,通过系统双盲法将其分成对照组(n=29)与试验组(n=30)。对照组患者采用苦参汤治疗,试验组患者采用加味蛇床子汤治疗。比较两组疗效、中医症状积分、外周血嗜酸性粒细胞(EOS)、C反应蛋白(CRP)水平、治疗起效时间、皮肤生活质量评分、瘙痒程度评分及治疗后1年的复发率。结果:试验组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组肛周瘙痒、便溏腹胀、食少乏力积分比较,差异均无统计学意义(P>0.05);治疗后,两组肛周瘙痒、便溏腹胀、食少乏力积分均低于治疗前,且试验组均低于对照组,差异均有统计学意义(P<0.05)。治疗前,两组EOS及CRP水平比较,差异均无统计学意义(P>0.05);治疗后,两组EOS及CRP水平均低于治疗前,且试验组均低于对照组,差异均有统计学意义(P<0.05)。治疗前,两组生活质量评分、肛周瘙痒程度评分比较,差异无统计学意义(P>0.05);治疗后,试验组生活质量评分、肛周瘙痒程度评分均低于对照组,差异均有统计学意义(P<0.05)。两组治疗起效时间比较,差异无统计学意义(P>0.05)。治疗1年后随访结果提示两组均未见复发。结论:湿热下注型肛门湿疹患者应用加味蛇床子汤有助于促进病情改善且能够显著减轻炎症反应与瘙痒感,能够控制复发率并可使患者生活质量获得提高,值得临床应用。Objective:To compare the therapeutic effects of modified Shechuangzi Decoction and Kushen Decoction in patients with damp-heat type anal eczema.Method:A total of 59 patients with anal eczema of damp-heat type in Quanzhou Hospital of Traditional Chinese Medicine from June 2015 to June 2020 were selected,they were divided into control group(n=29)and the experimental group(n=30)according to systematic double-blind method.The patients in the control group were treated with Kushen Decoction and the patients in the experimental group were treated with modified Shechuangzi Decoction.The curative effect,traditional Chinese medicine symptom scores,peripheral blood eosinophil(EOS),C reactive protein(CRP)levels,treatment onset time,skin quality of life scores,itching degree scores and recurrence rate 1 year after treatment were compared between the two groups.Result:The total effective rate of the experimental group was higher than that of the control group,the difference was statistically significant(P<0.05).Before treatment,there were no statistically significant differences in perianal pruritus,loose stool,abdominal distension,lack of food and fatigue scores between the two groups(P>0.05);after treatment,the perianal pruritus,loose stool,abdominal distension,lack of food and fatigue scores of both groups were lower than those before treatment,and those of the experimental group were lower than those of the control group,the differences were statistically significant(P<0.05).Before treatment,there were no statistically significant differences in EOS and CRP levels between the two groups(P>0.05);after treatment,the EOS and CRP levels of both groups were lower than those before treatment,and those of the experimental group were lower than those of the control group,the differences were statistically significant(P<0.05).Before treatment,there were no statistically significant differences in the quality of life scores and perianal pruritus scores between the two groups(P>0.05);after treatment,the quality of life scores and pe

关 键 词：加味蛇床子汤 湿热下注型 肛门湿疹 炎症反应 外周血嗜酸性粒细胞 苦参汤 

分 类 号：R275.9[医药卫生—中西医结合]