滋阴补髓方结合阿仑膦酸钠在老年骨质疏松性椎体压缩性骨折椎体成形术后的应用效果  

Application Effect of Ziyin Busui Recipe Combined with Alendronate Sodium in Elderly Patients with Osteoporotic Vertebral Compression Fracture after Vertebroplasty

作　　者：周明[1,2] 张曦 高俊[1] 魏康 薛峰[1] 陶宏明[1] ZHOU Ming;ZHANG Xi;GAO Jun;WEI Kang;XUE Feng;TAO Hongming(Changzhou Traditional Chinese Medicine Hospital,Jiangsu Province,Changzhou 213003,China)

机构地区：[1]江苏省常州市中医医院,江苏常州213003 [2]江苏省名老中医药专家张曦传承工作室

出　　处：《中国医学创新》2022年第27期76-80,共5页Medical Innovation of China

摘　　要：目的:探讨滋阴补髓方结合阿仑膦酸钠在老年骨质疏松性椎体压缩性骨折椎体成形术中的应用效果。方法:选取2020年1月-2021年1月常州市中医医院收治的76例老年骨质疏松性椎体压缩性骨折患者,将患者以SAS软件的随机数模块分成两组,各38例。两组均以椎体成形术治疗,术后对照组患者服用阿仑膦酸钠,观察组在对照组的基础上服用滋阴补髓方治疗。比较两组骨密度、骨形成标志物指标、血液流变学指标及疗效。结果:治疗前,两组骨密度比较,差异无统计学意义(P>0.05);治疗3个月,两组骨密度均高于治疗前,且观察组高于对照组,差异均有统计学意义(P<0.05)。治疗前,两组血清碱性磷酸酶(ALP)、血清Ⅰ型前胶原N-端前肽(PⅠNP)比较,差异均无统计学意义(P>0.05);治疗3个月,两组ALP、PⅠNP水平均高于治疗前,且观察组均高于对照组,差异均有统计学意义(P<0.05)。治疗前,两组血细胞比容(HCT)、红细胞沉降率(ESR)、纤维原蛋白(FIB)比较,差异均无统计学意义(P>0.05);治疗3个月,观察组HCT、ESR、FIB指标水平均低于治疗前,且均低于对照组,差异均有统计学意义(P<0.05)。观察组总有效率为94.74%,高于对照组的71.05%,差异有统计学意义(P<0.05)。结论:在治疗老年骨质疏松性椎体压缩性骨折患者中应用滋阴补髓方结合阿仑膦酸钠,可促进骨密度的提升,使骨折愈合质量提升。Objective:To explore the application effect of Ziyin Busui Recipe combined with Alendronate Sodium in elderly patients with osteoporotic vertebral compression fracture after vertebroplasty.Method:A total of 76 elderly patients with osteoporotic vertebral compression fracture admitted to Changzhou Traditional Chinese Medicine Hospital from January 2020 to January 2021 were selected,the patients were divided into two groups according to the random number module of SAS software,with 38 cases in each group.Both groups were treated with vertebroplasty.After operation,the control group was treated with Alendronate Sodium,and the observation group was treated with Ziyin Busui Recipe on the basis of the control group.Bone mineral density,bone formation markers,hemorheology indexes and curative effect were compared between the two groups.Result:Before treatment,there was no significant difference in bone mineral density between the two groups(P>0.05);after 3 months of treatment,the bone mineral density of both groups were higher than those before treatment,and the bone mineral density of the observation group was higher than that of the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in serum alkaline phosphatase(ALP)and serum N-terminal propeptide of typeⅠprocollagen(PⅠNP)between the two groups(P>0.05);after 3 months of treatment,the levels of ALP and PⅠNP of both groups were higher than those before treatment,and those of the observation group were higher than those of the control group,the differences were statistically significant(P<0.05).Before treatment,there were no statistically significant differences in hematocrit(HCT),erythrocyte sedimentation rate(ESR)and fibrinogen(FIB)between the two groups(P>0.05);after 3 months of treatment,the levels of HCT,ESR and FIB of the observation group were lower than those before treatment,and lower than those of the control group,the differences were statistically significant(P<0.05).The total effe

关 键 词：滋阴补髓方 阿仑膦酸钠 椎体压缩性骨折 骨质疏松 骨密度 

分 类 号：R687.3[医药卫生—骨科学]