微球囊压迫下行PTCA对冠心病患者IP-10、CK-MB水平的影响  

Effect of PTCA under Microballoon Compression on the Levels of IP-10 and CK-MB in Patients with Coronary Heart Disease

作　　者：张立敏[1] ZHANG Limin(Jiamusi Central Hospital,Heilongjiang Province,Jiamusi 154002,China)

机构地区：[1]黑龙江省佳木斯市中心医院,黑龙江佳木斯154002

出　　处：《中国医学创新》2022年第27期146-150,共5页Medical Innovation of China

摘　　要：目的:分析在微球囊压迫下行经皮冠状动脉腔内血管成形术(PTCA)对冠心病患者趋化因子干扰素诱导蛋白-10(IP-10)和心肌型肌酸激酶同工酶(CK-MB)水平的影响。方法:选取2019年1月-2021年12月佳木斯市中心医院收治的80例冠心病患者,按照随机数字表法将患者分成研究组和对照组,每组40例。研究组在微球囊压迫下行PTCA,对照组采用经皮冠状动脉介入治疗术(PCI)。比较两组手术效果。结果:术后1周,研究组左心室射血时间(LVET)、心脏等容收缩时间(ICT)、血小板聚集率及黏附率均低于对照组(P<0.05);术后3 d,研究组血清中IP-10与CK-MB水平均低于对照组,差异均有统计学意义(P<0.05)。结论:PTCA能够缓解冠心病患者病症,同时降低血清IP-10与CK-MB因子水平,以改善其体内细胞组织受损程度,加快患者术后病情恢复,具有推广价值。Objective:To analyze the effect of percutaneous transluminal coronary angioplasty(PTCA)under microballoon compression on the levels of chemokine interferon inducible protein-10(IP-10)and myocardial creatine kinase isoenzyme(CK-MB)in patients with coronary heart disease.Method:A total of 80 patients with coronary heart disease admitted to Jiamusi Central Hospital from January 2019 to December 2021 were selected,according to the random number table method,the patients were divided into the study group and the control group,with 40 patients in each group.The study group was treated with PTCA under microballoon compression,and the control group was treated with percutaneous coronary intervention(PCI).The surgical effect were compared between the two groups.Result:One week after operation,the left ventricular ejection time(LVET),cardiac isovolumic contraction time(ICT),platelet aggregation rate and adhesion rate in the study group were lower than those in the control group(P<0.05);3 days after operation,the levels of IP-10 and CK-MB in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion:PTCA can relieve the symptoms of patients with coronary heart disease,and reduce the levels of serum IP-10 and CK-MB factors,so as to improve the degree of damage of cells and tissues in vivo and accelerate the recovery of patients after operation,it is worth popularizing.

关 键 词：微球囊压迫 冠心病 经皮冠状动脉腔内血管成形术 趋化因子干扰素诱导蛋白-10 心肌型肌酸激酶同工酶 

分 类 号：R541.4[医药卫生—心血管疾病]