燕麦生物碱敷料联合红光照射治疗玫瑰痤疮的效果及对皮肤屏障、Th1/Th2细胞水平的影响  

Effect of Avenanthramide Dressing Combined with Red Light Irradiation in the Treatment of Acne Rosacea and Its Influence on Skin Barrier and Th1/Th2 Cell Level

作　　者：朱坤 熊菲 潘莉 宋秋荷 童务华 聂香妮 ZHU Kun;XIONG Fei;PAN Li;SONG Qiuhe;TONG Wuhua;NIE Xiangni(Affiliated Hospital of Jiujiang University,Jiujiang 332000,China;不详)

机构地区：[1]九江学院附属医院,江西九江332000 [2]江西省九江市妇幼保健院

出　　处：《中国医学创新》2022年第29期57-61,共5页Medical Innovation of China

基　　金：江西省卫生厅科技计划项目(20177138)。

摘　　要：目的:探究燕麦生物碱敷料联合红光照射治疗玫瑰痤疮的效果及对皮肤屏障、Th1/Th2细胞水平的影响。方法:选取九江学院附属医院皮肤科于2021年2-10月收治的110例玫瑰痤疮患者为研究对象,按照随机数字表法分为观察组和对照组,各55例。对照组给予红光照射治疗,观察组在对照组的基础上加用燕麦生物碱敷料治疗。比较两组治疗4、8周后临床疗效,治疗前及治疗后临床症状评分[医师红斑评估量表(CEA)、患者自评量表(PSA)、皮肤病生活质量指数(DLQI)]、皮肤屏障功能及Th1/Th2细胞[γ干扰素(IFN-γ)、肿瘤坏死因子-α(TNF-α)、白介素-4(IL-4)]水平变化情况。结果:治疗4周后,观察组临床总有效率为85.45%,对照组为69.09%,差异有统计学意义(P<0.05);治疗8周后,观察组临床总有效率为96.36%,对照组为87.27%,差异无统计学意义(P>0.05);与治疗前比较,治疗4、8周后,两组CEA、PSA、DLQI评分均降低(P<0.05),TEWL、红斑指数均降低(P<0.05),表皮油脂和表皮含水量均升高(P<0.05),IFN-γ水平均升高(P<0.05),TNF-α、IL-4水平均降低(P<0.05),且观察组改善程度均优于对照组(P<0.05)。结论:燕麦生物碱敷料联合红光照射治疗玫瑰痤疮可显著提高临床效果,加快症状及炎症缓解,促进皮肤屏障功能修复。Objective:To explore the efficacy of avenanthramide dressing combined with red light irradiation in the treatment of acne rosacea and its influence on skin barrier and Th1/Th2 cell level.Method:A total of 110 patients with acne rosacea treated in Department of Dermatology of Affiliated Hospital of Jiujiang University from February 2021 to October 2021 were selected as the research subjects,and they were divided into the observation group and the control group according to the random number table method,with 55 cases in each group.The control group was treated with red light irradiation,while the observation group was additionally given avenanthramide dressing on the basis of the control group.The clinical efficacy of the two groups was compared after 4 and 8 weeks of treatment, scores of clinical symptoms [clinician’s erythema assessment (CEA), patient self assessment (PSA), dermatology life quality index (DLQI)], skin barrier and levels of Th1/Th2 cell [γ-interferon (IFN-γ), tumor necrosis factor-α (TNF-α), interleukin-4 (IL-4)] before and after treatment were compared between the two groups. Result: After 4 weeks of treatment, the total effective rate was 85.45% in the observation group and 69.09% in the control group, the difference was statistically significant (P<0.05);after 8 weeks of treatment, the total effective rate was 96.36% in the observation group and 87.27% in the control group, the difference was not statistically significant (P>0.05). Compared with before treatment, after 4 and 8 weeks after treatment, the scores of CEA, PSA and DLQI in the two groups were decreased (P<0.05), the TEWL and the erythema index were reduced (P<0.05), the epidermal grease and epidermal water content were enhanced (P<0.05), IFN-γ level was increased (P<0.05), while the levels of TNF-α and IL-4 were decreased (P<0.05), and the improvement degrees in the observation group were significantly better than those in the control group (P<0.05). Conclusion: Avenanthramide dressing combined with red light irradiation in

关 键 词：燕麦生物碱敷料 红光照射 玫瑰痤疮 皮肤屏障 皮肤红斑 

分 类 号：R758.734[医药卫生—皮肤病学与性病学]