小剂量右美托咪定麻醉对子宫肌瘤腹腔镜手术患者复苏时间及TAS、MDA水平的影响  

Effects of Low Dose Dexmedetomidine Anesthesia on Resuscitation Time and Levels of TAS and MDA in Patients Undergoing Laparoscopic Hysteromyoma Surgery

作　　者：刘琳琳 黄小梅 LIU Linlin;HUANG Xiaomei(Affiliated Maternity and Child Health Care Hospital of Nantong University,Nantong 226000,China;不详)

机构地区：[1]南通大学附属妇幼保健院,江苏南通226000

出　　处：《中国医学创新》2022年第29期62-65,共4页Medical Innovation of China

摘　　要：目的:探讨小剂量右美托咪定麻醉对子宫肌瘤腹腔镜手术患者复苏时间及总抗氧化态(TAS)和丙二醛(MDA)水平的影响。方法:选取2017年12月-2021年12月南通大学附属妇幼保健院收治的106例拟行子宫肌瘤腹腔镜手术患者,依照随机数字表法分为对照组和观察组,每组53例。麻醉诱导前对照组给予1.0μg/(kg·h)右美托咪定,观察组给予0.5μg/(kg·h)的右美托咪定。比较两组患者复苏时间、拔管时间以及视觉模拟评分法(VAS)评分和TAS、MDA水平。结果:观察组患者复苏时间、拔管时间均短于对照组,差异均有统计学意义(P<0.05)。两组患者术后6、12 h的VAS评分均低于术后4 h,术后12 h的VAS评分均低于术后6 h,且观察组术后4、6、12 h的VAS评分均低于对照组,差异均有统计学意义(P<0.05)。两组患者术前TAS、MDA水平对比,差异均无统计学意义(P>0.05);两组患者术后1 d的TAS水平均低于术前,MDA水平均高于术前,但观察组患者TAS水平高于对照组,MDA水平低于对照组,差异均有统计学意义(P<0.05)。结论:小剂量右美托咪定麻醉应用于子宫肌瘤腹腔镜手术患者,能够缩短复苏时间以及拔管时间,缓解疼痛感以及应激反应,具有一定的推广应用价值。Objective:To investigate the effects of low dose Dexmedetomidine anesthesia on the recovery time and the levels of total antioxidant state(TAS)and malondialdehyde(MDA)in patients undergoing laparoscopic surgery for hysteromyoma.Method:From December 2017 to December 2021,106 patients with uterine myoma undergoing laparoscopic surgery in Affiliated Maternity and Child Health Care Hospital of Nantong University were selected and divided into control group and observation group according to the random number table method,with 53 cases in each group.Before anesthesia induction,the control group was given 1.0μg/(kg·h)Dexmedetomidine,the observation group was given 0.5μg/(kg·h)Dexmedetomidine.The resuscitation time,extubation time,visual analogue scale(VAS),TAS and MDA levels were compared between the two groups.Result:The resuscitation time and extubation time of the observation group were shorter than those of the control group,the differences were statistically significant(P<0.05).The VAS scores at 6 h and 12 h after surgery in the two groups were lower than those at 4 h after surgery,the VAS scores at 12 h after surgery were lower than those at 6 h after operation,and the VAS scores at 4,6 and 12 h after surgery in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).There were no significant differences in preoperative TAS and MDA levels between the two groups(P>0.05);the levels of TAS of patients in the two groups at 1 d after surgery were lower than those before surgery,the levels of MDA were higher than those before surgery,but the TAS of the observation group was higher than that of the control group,and the MDA was lower than that of the control group,the differences were statistically significant(P<0.05).Conclusion:The application of low dose Dexmedetomidine anesthesia in patients undergoing laparoscopic surgery for hysteromyoma can shorten the recovery time and extubation time,relieve pain and stress response,and has certain popularizatio

关 键 词：右美托咪定 子宫肌瘤 腹腔镜手术 应激反应 总抗氧化态 丙二醛 

分 类 号：R614[医药卫生—麻醉学] R737.33[医药卫生—外科学]