抗MPO和PR3-ANCA相关性血管炎临床特征比较  被引量:2

Comparison of Clinical Features of Anti-MPO and PR3-ANCA-associated Vasculitis

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作  者:张红[1] 曹晶[1] 王鸣军[1] ZHANG Hong;CAO Jing;WANG Mingjun(Department of Rheumatology,the First Affiliated Hospital of Soochow University,Suzhou,Jiangsu Province,215006 China)

机构地区:[1]苏州大学附属第一医院风湿科,江苏苏州215006

出  处:《系统医学》2022年第17期9-12,17,共5页Systems Medicine

基  金:苏州市科技计划项目(SYS2019043)。

摘  要:目的比较MPO与PR3-ANCA相关性血管炎(associated vasculitis,AAV)的临床特征及实验室检查。方法收集苏州大学附属第一医院2013年1月-2021年4月160例确诊为AAV患者的临床表现、实验室检查及影像学检查等资料,分为MPO组及PR3组,其中MPO组141例,PR3组19例,对两组病例进行回顾性分析。结果160例患者中有141例(88.13%)为MPO-AAV,MPO组发病年龄大于PR3组,差异有统计学意义(Z=-2.349,P=0.019);MPO组肌酐水平高于PR3组,差异有统计学意义(Z=-2.405,P=0.016);MPO组白细胞水平高于PR3组,差异有统计学意义(Z=-2.387,P=0.017);MPO组血红蛋白水平低于PR3组,差异有统计学意义(Z=-2.411,P=0.016)。两组在ESR、CRP、PLT、ALB等指标上差异无统计学意义(P>0.05)。MPO组肾脏受累更常见,PR3组呼吸系统受累更常见。结论MPO组更易累及肾脏、血液系统。两组血管炎在临床表现及相关检查上具有差异。Objective To compare the clinical features and laboratory tests of MPO and PR3-ANCA-associated vasculitis(AAV).Methods The clinical manifestations,laboratory examinations and imaging examinations of 160 patients diagnosed with AAV in the First Affiliated Hospital of Soochow University from January 2013 to April 2021 were collected.They were divided into MPO group and PR3 group,including 141 cases in MPO group and 19 cases in PR3 group.Retrospective analysis of the two groups of cases.Results Among the 160 patients,141(88.13%)were MPO-AAV.The age of onset in the MPO group was greater than that in the PR3 group,and the difference was statistically significant(Z=-2.349,P=0.019);the creatinine level in the MPO group was higher than that in the PR3 group,and the difference was statistically significant(Z=-2.405,P=0.016);the white blood cell level in the MPO group was higher than that in the PR3 group,and the difference was statistically significant(Z=-2.387,P=0.017);the hemoglobin level in the MPO group was lower than that in the PR3 group,and the difference was statistically significant(Z=-2.411,P=0.016).There was no statistically significant difference in ESR,CRP,PLT,ALB and other indicators between the two groups(P>0.05).Renal involvement was more common in the MPO group and respiratory system involvement was more common in the PR3 group.Conclusion MPO group is more likely to involve kidney and blood system.There were differences in clinical manifestations and related examinations between the two groups of vasculitis.

关 键 词:ANCA 血管炎 临床特征 

分 类 号:R4[医药卫生—临床医学]

 

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