盐酸利托君在先兆早产中的保胎效果及对宫颈IGFBP-1、IL-6及MMP-8的影响  

The Effect of Ritodrine Hydrochloride on Abortion in Threatened Preterm Labor and the Effect on Cervical IGFBP-1,IL-6 and MMP-8

作　　者：杨秀莲[1] YANG Xiulian(Department of Obstetrics and Gynecology,Huizhou Third People's Hospital,Huizhou,Guangdong Province,516000 China)

机构地区：[1]惠州市第三人民医院妇产科,广东惠州516000

出　　处：《系统医学》2022年第17期159-162,174,共5页Systems Medicine

摘　　要：目的探讨盐酸利托君在先兆早产中的临床应用价值。方法纳入2017年5月-2021年11月惠州市第三人民医院产科收治的先兆早产患者共86例为研究对象,按随机数表法分为两组。对照组43例用硫酸镁治疗,观察组43例在对照组用药基础上加用盐酸利托君,评估保胎效果,观察用药前和用药后血清指标、宫颈分泌物相关指标改变情况,随访至分娩,记录围生儿结局。结果观察组与对照组保胎成功率(93.02%vs 76.74%)比较,差异有统计学意义(χ^(2)=4.441,P<0.05)。治疗后,两组干扰素-γ(IFN-γ)和肿瘤坏死因子-α(TNF-α)水平均比治疗前低,白细胞介素-4(IL-4)和白细胞介素-10(IL-10)水平均比治疗前高,差异有统计学意义(P<0.05);观察组IFN-γ、TNF-α水平低于对照组,IL-4和IL-10水平高于对照组,差异有统计学意义(P<0.05)。治疗后,两组宫颈磷酸化胰岛素样生长因子-1(IGFBP-1)、白细胞介素-6(IL-6)和基质金属蛋白酶-8(MMP-8)水平均比治疗前低,差异有统计学意义(P<0.05);观察组IGFBP-1、IL-6和MMP-8水平低于对照组,差异有统计学意义(P<0.05)。观察组宫缩消失时间较对照组缩短,妊娠延长时间较对照组长,Apgar评分较对照组高,差异有统计学意义(P<0.05)。两组低体重儿和新生儿病死率比较,差异无统计学意义(P>0.05)。结论盐酸利托君治疗先兆早产能提高保胎效果、改善宫颈IGFBP-1、IL-6、MMP-8及血清细胞因子水平、减少低体重儿和新生儿死亡。Objective To investigate the clinical application value of ritodrine hydrochloride in threatened preterm labor.Methods A total of 86 patients with threatened preterm birth admitted to Department of Obstetrics,the Third People's Hospital of Huizhou from May 2017 to November 2021 were included as research objects and divided into 2 groups according to the random number table method.43 cases in the control group were treated with magnesium sulfate,and 43 cases in the observation group were additionally treated with ritodrine hydrochloride on the basis of the medication in the control group.The effect of pregnancy protection was evaluated,the changes of serum indexes and cervical secretion-related indexes before and after administration were observed,followed up until delivery,and perinatal outcomes were recorded.Results Compared with the control group,the success rate of miscarriage protection in the observation group was higher(93.02%vs 81.40%),and the observation group was higher than the control group,the difference was statistically significant(χ^(2)=4.441,P<0.05).After treatment,two groups of interferonγ(IFNγ)and tumor necrosis factorα(TNFα)level were lower than those before treatment,the difference was statistically significant(P<0.05);the level of IFN-γand TNF-αin the observation group were lower those that in the control group,and the level of IL-4 and IL-10 were higher than those in the control group,and the difference was statistically significant(P<0.05).After treatment,two groups of cervical phosphorylated insulin-like growth factor-1(IGFBP-1),interleukin-6(IL-6)and matrix metalloproteinase-8(MMP-8)level were lower than those before treatment,the difference was statistically significant(P<0.05);compared with the control group,IGFBP-1,IL-6 and MMP-8 in the observation group were significantly decreased,and the difference was statistically significant(P<0.05).The disappearance time of uterine contractions in the observation group was shorter than that in the control group,the prolongation time of pr

关 键 词：盐酸利托君 先兆早产 硫酸镁 宫颈分泌物 

分 类 号：R71[医药卫生—妇产科学]