补肾健脾法预防经尿道前列腺等离子双极汽化电切术(TUPKVP)后并发症的疗效观察  

Prevention of Complications afterTransurethral Plasmakinetic Vaporization of Prostate(TUPKVP)by Tonifying Kidney and Invigorating Spleen

作　　者：梁霄[1] 周杰彬[1] 卢尚光[1] 罗向东[1] 吴刚[1] LIANG Xiao;ZHOU Jie-bin;LU Shang-guang;LUO Xiang-dong;WU Gang(Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine,Nanning Guangxi 530011)

机构地区：[1]广西中医药大学附属瑞康医院,广西南宁530011

出　　处：《世界中西医结合杂志》2022年第6期1223-1227,1233,共6页World Journal of Integrated Traditional and Western Medicine

基　　金：广西壮族自治区卫生和计划生育委员会自筹经费科研项目(Z2016212)。

摘　　要：目的观察补肾健脾法预防经尿道前列腺等离子双极汽化电切术(Transurethral bipolar Plasmakinetic prostatectomy,TUPKVP)术后并发症的疗效。方法选取2015年1月—2018年12月期间广西中医药大学附属瑞康医院泌尿外科住院的80例良性前列腺增生患者作为研究对象,随机分为治疗组和对照组,每组各40例。两组患者均接受TUPKVP,对照组患者给予围术期常规治疗,治疗组在对照组基础上口服补肾健脾通淋汤,两组患者均持续治疗1周。观察两组患者手术前后最大尿流率(Maximum flow rate,Qmax)、最大膀胱容量(Maximum cystometric capacity,MCC)、膀胱顺应性(Bladder compliance,BC)、最大逼尿肌压力(Pressure of detrusor maximum,Pdet.max)、剩余尿量(Residual urine,PVR)、国际前列腺症状评分(International Prostate Symptom Score,IPSS)、慢性前列腺炎症状评分(INH-CPSI)、生活质量评分(Quality of life,QOL)、雌二醇(Estradiol,E_(2))、黄体生成素(luteinizing hormone,LH)、促卵泡素((Follicle stimulating hormone,FSH)、睾酮(Testosterone,T)和催乳素(Prolactin,PRL)水平、血清白细胞介素-6(Interleukin 6,IL-6)、白细胞介素-8(Interleukin 8,IL-8)水平变化及术后留置尿管时间、冲洗膀胱时间和住院时间和术后并发症情况。结果两组患者术后的Qmax、MCC、BC较术前均明显升高,Pdet.max、PVR较术前均明显降低,差异有统计学意义(P<0.05);且治疗组术后的Qmax、MCC、BC较对照组均明显升高,Pdet.max、PVR较对照组均明显降低,差异有统计学意义(P<0.05)。术后两组患者的INH-CPSI、IPSS、QOL评分较术前均明显降低,差异有统计学意义(P<0.05);且治疗组术后INH-CPSI、IPSS、QOL评分均明显低于对照组,差异有统计学意义(P<0.05)。术后两组患者的血清IL-6、IL-8水平较术前均明显降低,差异有统计学意义(P<0.05);且治疗组术后血清IL-6、IL-8水平均明显低于对照组,差异有统计学意义(P<0.05)。术后两组患者的血清E_(2Objective To observe the effect of tonifying kidney and invigorating spleenon the prevention of complications aftertransurethral plasmakinetic vaporization of prostate(TUPKVP).Methods Eighty patients with benign prostatic hyperplasia(BPH)who were hospitalized in the Department of Urology,Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine from January 2015 to December 2018 were selected as the research objects,and randomly divided into a treatment group and a control group,with 40 cases in each group.Patients in theboth groups received TUPKVP.The control group received routine perioperative treatment,and the treatment group received Bushen Jianpi Tonglin Decoction orallyon the basis of the treatment in the control group.The treatment lasted for 1 week in both groups.Maximum flow rate(Qmax),maximum cystometric capacity(MCC),bladder compliance(BC),pressure of detrusor maximum(Pdet.max),residual urine(PVR),international prostate symptom score(IPSS),National Institutes of Health-chronic prostatitis symptom index(NIH-CPSI),quality of life(QOL),estradiol(E_(2)),luteinizing hormone(LH),follicle stimulating hormone(FSH),testosterone(T),and prolactin(PRL)levels,serum interleukin-6(IL-6),interleukin-8(IL-8)level changes before and after surgery were compared between the two groups.The postoperative indwelling catheter time,bladder flushing time,hospital stay,and complications were compared between the two groups.Results The postoperative Qmax,MCC,and BC of patients in the two groups were significantly improved,while Pdet.max and PVR were significantly decreased(P<0.05).As compared with the control group,the postoperative Qmax,MCC,and BC in the treatment group were significantly higher,while Pdet.max and PVR were significantly lower(P<0.05).The postoperative NIH-CPSI,IPSS,and QOL of patients in the two groups were significantly lower(P<0.05),and the treatment group were significantly lower than the control group(P<0.05).The postoperative serum levels of IL-6 and IL-8 in the two groups were significantly lo

关 键 词：前列腺增生 经尿道前列腺等离子双极汽化电切术 补肾健脾法 术后并发症 尿动力学 炎症因子 性激素 

分 类 号：R697.32[医药卫生—泌尿科学]