负性生活事件对大学生抑郁的影响:网络成瘾的中介与5-HTR1A基因rs749098多态性的调节作用  

The Effect of Negative Life Events on College Students’Depression:The Mediating Role of Internet Addiction and the Moderation Role of 5-HTT1A Gene rs749098 Polymorphism

作　　者：曾子豪 胡义秋[1,2] 彭丽仪 詹林 刘双金 欧阳晓优 丁道群 黎志华[5] Zeng Zihao;Hu Yiqiu;Peng Liyi;Zhan Lin;Liu Shuangjin;Ouyang Xiaoyou;Ding Daoqun;Li Zhihua(School of Educational Science,Hunan Normal University,Changsha,410081;Key Laboratory for Cognition and Human Behavior of Hunan Province,Department of Psychology,Changsha,410083;Hunan Normal University Library,Changsha,410081;Hunan Mass Media College,Changsha,410100;College of Teachers Education,Ningbo University,Ningbo,315211)

机构地区：[1]湖南师范大学教育科学学院,长沙410081 [2]认知与人类行为湖南省重点实验室,长沙410081 [3]湖南师范大学图书馆,长沙100814 [4]湖南大众传媒职业技术学院,长沙410100 [5]宁波大学教师教育学院,宁波315211

出　　处：《心理科学》2022年第3期599-606,共8页Journal of Psychological Science

基　　金：全国教育科学“十二五”规划国家一般项目“大学生抑郁症易感性:基因多态性与社会心理因素共同作用”(项目编号:BBA140047);湖南省社会科学基金项目“大学生心理危机预警系统研究”(项目编号:19YBA247)的资助。

摘　　要：基于抑郁的基因-环境研究范式,以301名大学生为研究对象,探究负性生活事件对大学生抑郁的影响及作用机制。结果表明:(1)负性生活事件、网络成瘾与大学生抑郁两两显著相关;(2)网络成瘾在负性生活事件对大学生抑郁的影响中起部分中介作用;(3)5-HTR1A基因rs749098多态性在该中介模型的直接路径和中介后半段起调节效应,具体表现为,相比携带C/G和G/G基因型个体,C/C基因型个体负性生活事件对抑郁的负向预测更强,且携带C/C基因型的个体,即使是低水平的网络成瘾的都表现出更高的抑郁情况,而在高水平的网络成瘾的情况下三种基因型都表现出高水平的抑郁。With the rapid development of social economy and increasingly fierce competition,college students who are lack of social experience and powerful self-adjustment ability have a higher risk of depression.The high incidence and harmfulness of depression make it an important research content of psychology,sociology and psychiatry to explore the influencing factors and mechanism of college students’depression.Some empirical studies have proved that negative life events are a risk factor for college students’depression.However,the mechanism(mediating and regulating effect)of negative life events on college students’depression still needs further investigation.Studies have shown that when individuals are facing negative life events,they are more likely to turn to the Internet to escape the frustration of life pressure and become addicted to the Internet,and Internet addiction is often significantly positively correlated with depression.The diathesis-stress model of depression suggests that individuals are more sensitive to stressful events in the environment because they carry certain vulnerability qualities,thus leading to depression.Therefore,we brought Internet addiction and 5-HTT1A gene rs749098 polymorphism into the currents and constructed a moderated mediator model to explore the mechanism of negative life events on college students’depression.A total of 301 college students(74 boys and 227 girls)participated in this investigation.After given informed consents,they completed Center for Epidemiological Studies Depression Scale,Adolescent Self-rating Life Events Check List and The Chinese Version of the Internet Addiction Scale.Professional nurses extracted 2.5 ml venous blood in EDTA anticoagulant tube(blood:EDTA=5:1)from the participants in the study,then placed it in the refrigerator(-70℃),and extracted DNA and parted after three months.All these data were analyzed by the software of SPSS24.0 and Amos 24.0.The result showed that:(1)negative life events,Internet addiction and college students’depressi

关 键 词：负性生活事件 网络成瘾 大学生抑郁 5-HTR1A 基因 

分 类 号：G444[哲学宗教—心理学]