妊娠期高血压患者外周血miR-210表达与UACR、MDA、SOD、T-AOC、TNF-α及IL-6的关系  

Analysis of clinical efficacy between polypropylene mesh preperitoneal space repair and polypropylene and polylactic acid mesh hernia repair

作　　者：孙莎 高志敏 武丽蕊 袁克芳 李红霞 Sun Sha;Gao Zhi-min;Wu Li-rui;Yuan Ke-fang;Li Hong-xia(Hebei Petro China Center Hospital,Langfang 065000,China)

机构地区：[1]河北中石油中心医院,廊坊065000

出　　处：《湖南师范大学学报（医学版）》2022年第4期94-97,共4页Journal of Hunan Normal University(Medical Sciences)

基　　金：廊坊市科技支撑计划项目(2020013132)。

摘　　要：目的:探索外周血miR-210与妊娠期高血压患者表达水平及临床指标的相关性。方法:取我院 2020年7月~2022年3月138例妊娠期高血压疾病患者作为研究对象,作为研究组,据病情程度分为三组:妊娠期高血压亚组(n=34,A组)、轻度子痫前期亚组(n=79,B组)、重度子痫前期亚组(n=25,C组),取50例单胎健康孕妇为对照组。比较两组血清 miR-210 表达水平及血清炎性因子如白细胞介素6(IL-6)、肿瘤坏死因子-α(TNF-α),氧化应激指标如丙二醛(MDA)、超氧化物歧化酶(SOD)、总抗氧化能力(T-AOC)及尿微量白蛋白/肌酐比值(UACR),并分析血清miR-210 与UACR、MDA、SOD、T-AOC、TNF-α及IL-6的相关性。结果:研究组患者miR-210、IL-6、TNF-α均高于对照组;研究组患者SOD、T-AOC水平均低于对照组,UACR、MAD水平高于对照组;B组miR-210、IL-6、TNF-α水平高于A组,且C组miR-210、IL-6、TNF-α水平高于B组;SOD、T-AOC水平在A组、B组、C组中依次降低,UACR、MAD水平在A组、B组、C组中依次升高;A组清miR-210 与 TNF-α、IL-6、MAD、UACR呈正相关,与 SOD、T-AOC呈负相关。结论:miR-210 通过介导炎性反应、氧化应激、血管内皮细胞的损伤过程而参与 HDCP 疾病发生发展,可作为临床诊断HDCP 的生物标志物。Objective To explore the corelation betwen peripheral blood miR-210 and he expresion evel and clinical indicators in patients with gestational hypertension Methods A total of 138 patients with gestationa hypetension in our hospita from July2020 toMarch 2022 were selected asthe research subjectsrecorded as the study group,and divided into3 group aceording tothe severity ofthe disease gestationa hypertension subgroup m-34.Agroup).mild preclampiasubgroup group(n=79 B group)severe peelampsia subgroupgroup(n=25.Cgroup)and 50 healthy singleton pregnant women were selected as the contol group during the same period The expresion levels of serum miR-21O and serum infammatory factors suchas nteleukin-6(L-6),tumor nerosis factor-α(TNF-a)and oxidative stres indieators such as malondialdehyde MDA)superoxide dismutase SOD)Total antioxidant capacity(T-AOCand urinary albumin/ereatine ratio(UACR).The Corelation between serum miR-210 and UACR,MDA,SOD,T-AOC,TNF-αand IL-6was also analyzed.Results miR-210,IL-6 and TNF-αin the study group wehigher han those in the control group the levels of SOD and T-AOC in the study group were lower than thosein the control group,and the levels of UACR and MAD in the study groupwere highe than thosein the control group:miR-210,IL-6,TNF-αlevels in B组were higher than those inA组,andmiR-210,IL-6,TNF-αin severe preeclampsia subgroup The levelsof SOD and T-AOC were owerin the A组B组,and C组in tum,and UACR,The levels of MAD increasedin the A组,B组,and severe preclampsia subgroup:Serum miR-210 and TNF-αin hypetensive disorder complicating pregnancy patients,L-6 MADUACR were positively conelted with SODT-AOC werenegatively corelated.Conclusion miR-21O is involved in the oecurence and development of HDCP by mediating inflammatory response oxidative stress,and vascular endothelial cel damage,and can be used as a biomarke for clinical diagnosis of HDCP.

关 键 词：白细胞介素6 肿瘤坏死因子-α 丙二醛 妊娠期高血压 

分 类 号：R714[医药卫生—妇产科学]