听力正常青年人普通话可接受噪声级与皮层听觉诱发电位的相关性研究  

Correlation between Mandarin acceptable noise level and cortical auditory evoked potential in young normal-hearing listeners

作　　者：陈建勇[1] 朱海月 沈佳丽 马孝宝 汪玮[1] 孙进 陈向平 杨军[1] CHEN Jianyong;ZHU Haiyue;SHEN Jiali;MA Xiaobao;WANG Wei;SUN Jin;CHEN Xiangping;YANG Jun(Department of Otorhinolaryngology-Head&Neck Surgery,Xinhua Hospital,Shanghai Jiaotong University School of Medicine,Shanghai Jiaotong University School of Medicine Ear Institute,Shanghai Key Laboratory of Translational Medicine on Ear and Nose diseases,Shanghai,200092,China)

机构地区：[1]上海交通大学医学院附属新华医院耳鼻咽喉-头颈外科上海交通大学医学院耳科学研究所上海耳鼻疾病转化医学重点实验室,上海200092

出　　处：《临床耳鼻咽喉头颈外科杂志》2022年第9期679-684,共6页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：国家自然科学基金面上项目(No:81970881);上海市科委项目(No:21S31900600);新华医院院级临床研究培育基金(No:21XHDB02)。

摘　　要：目的研究普通话可接受噪声级(M-ANL)与皮层听觉诱发电位(CAEP)的相关性,探讨导致M-ANL值个体化差异的可能机制。方法选取30例22~33岁听力正常青年人作为研究对象,分别进行M-ANL测试和CAEP测试,记录每位受试者的最舒适阈(MCL)值、最大背景噪声级(BNL)值、M-ANL值及CAEP中P1、N1、P2、N2、P300各波的潜伏期及P1-N1、P2-N2、P300的幅值。采用SPSS 25.0软件进行统计分析,探讨MCL值、BNL值及M-ANL值与CAEP各波潜伏期及P1-N1、P2-N2、P300幅值之间的相关性。结果①MCL值和M-ANL值与CAEP的P2潜伏期均呈正相关,相关系数分别为0.404和0.400,差异均有统计学意义(P<0.05);与CAEP的P1、N1、N2、P300潜伏期均无相关性(P>0.05)。②MCL、BNL及M-ANL值与CAEP的P1-N1、P2-N2及P300幅值均无相关性(P>0.05)。结论听力正常青年人M-ANL与CAEP存在一定的相关性,提示中枢听觉皮层在听力正常个体背景噪声耐受能力方面可能发挥一定的调节作用。背景噪声接受能力更强的个体或许存在更强的中枢传出机制和/或更不活跃的中枢传入机制。Objective To investigate the correlation between Mandarin acceptable noise level(M-ANL)and cortical auditory evoked potential(CAEP),and to explore the possible mechanism leading to individual differences in M-ANL values.Methods Thirty listeners aged 22-33 years with normal hearing were selected as the study subjects,and the M-ANL test and CAEP test were performed respectively.The most comfortable level(MCL),maximum background noise level(BNL),M-ANL and CAEP values of each subject were recorded.The latency of each wave of P1,N1,P2,N2,P300 and the amplitude of P1-N1,P2-N2,P300 in CAEP were recorded for each subject.SPSS 25.0 was used for statistical analysis to explore the correlation between the MCL value,BNL value and M-ANL values and the latency of P1,N1,P2,N2,P300 and P1-N1,P2-N2,P300 amplitudes of CAEP.Results①The MCL value and M-ANL value were positively correlated with the P2 latency of CAEP,and the correlation coefficients were 0.404 and 0.400,respectively,and the differences were statistically significant(P<0.05).There was no correlation with P1,N1,N2,and P300 latencies of CAEP(P>0.05).②The MCL value,BNL value and M-ANL value had no significant difference with the CAEP wave amplitudes of P1-N1,P2-N2,and P300(P>0.05).Conclusion There was a certain correlation between M-ANL and CAEP in young adults with normal hearing,suggesting that the central auditory cortex might play a potential regulatory role in the background noise tolerance.Individuals with a greater background noise acceptance might have stronger central efferent mechanisms and/or less active central afferent mechanisms.

关 键 词：普通话可接受噪声级 最大背景噪声级 皮层听觉诱发电位 P300 

分 类 号：R764[医药卫生—耳鼻咽喉科]