二维斑点追踪超声心动图评估结缔组织病合并肺动脉高压患者右室同步性的研究  

Evaluation of right ventricular dyssynchrony by two-dimensional speckle tracking echocardiography in patients of connective tissue disease-associated pulmonary arterial hypertension

作　　者：马红[1] 周蕾[1] 王嫱[2] 孙晓萱[2] 郑亚国 李新立[1] 吴红平[1] MA Hong;ZHOU Lei;WANG Qiang;SUN Xiaoxuan;ZHENG Yaguo;LI Xinli;WU Hongping(Department of Cardiology,the First Affiliated Hospital of Nanjing Medical University,Nanjing,210029,China;Department of Rheumatology,the First Affiliated Hospital of Nanjing Medical University;Department of Cardiology,Nanjing First Hospital,Nanjing Medical University)

机构地区：[1]南京医科大学第一附属医院心血管内科,南京210029 [2]南京医科大学第一附属医院风湿免疫科 [3]南京医科大学附属南京医院心血管内科

出　　处：《临床心血管病杂志》2022年第9期720-725,共6页Journal of Clinical Cardiology

基　　金：国家自然科学青年基金(No:81900248)。

摘　　要：目的:探讨二维斑点追踪超声心动图评估结缔组织病(CTD)患者右室同步性的变化及其诊断肺动脉高压(PAH)的价值。方法:前瞻性纳入2018年5月—2019年12月在风湿免疫科确诊的CTD患者111例,同期选取32例健康体检者作为正常对照。据超声估测肺动脉收缩压(sPAP)将111例CTD患者分为两组:肺动脉压力正常组(sPAP≤36 mmHg,1mmHg=0.133 kPa)60例,PAH组(sPAP>36 mmHg)51例。常规超声心动图获取左房前后径、左室前后径及左室射血分数;右房左右径、右室左右径及三尖瓣环收缩期位移(TAPSE)、右室面积变化率(FAC)及三尖瓣环收缩期峰值流速。二维斑点追踪超声心动图测量右室游离壁基底段与中间段纵向应变值、室间隔基底段与中间段纵向应变值,并计算上述4个右室壁应变达峰时间标准差(RV-SD4)。结果:与正常对照组相比,CTD患者右室游离壁纵向应变值显著减低(P<0.05),但右室RV-SD4明显增加(P<0.05);与CTD肺动脉压力正常组比较,PAH组右室游离壁纵向应变值明显减低(P<0.05),但右室RV-SD4亦明显增加(P<0.05)。Pearson相关性分析显示,RV-SD4与右室游离壁纵向应变(r=0.586,P<0.001)及sPAP(r=0.647,P<0.001)呈正相关;同时RV-SD4与TAPSE(r=-0.511,P<0.001)及FAC(r=-0.601,P<0.001)呈负相关。RV-SD4诊断PAH的ROC曲线下面积约0.777,灵敏度和特异度分别为67%和83%。结论:二维斑点追踪超声心动图中RV-SD4指标可有效反映CTD合并PAH患者右室壁收缩不同步,并随着sPAP升高,右室壁收缩不同步更显著。Objective:This study sought to investigate the clinical value of two-dimensional speckle tracking echocardiography for evaluating right ventricular dyssynchrony in patients of connective tissue disease-associated pulmonary arterial hypertension.Methods:A total of 111 patients with connective tissue disease(CTD)and 32 healthy controls were prospectively recruited.According to systolic pulmonary artery pressure(sPAP),the CTD patients were divided into 2 subgroups:CTD without pulmonary arterial hypertension(PAH)group(sPAP≤36 mmHg,n=60)and CTD-PAH group(sPAP>36 mmHg,n=51).The left atrium,left ventricle,left ventricular ejection fraction,right atrium,right ventricle,tricuspid annular plane systolic excursion(TAPSE),fractional area change(FAC)and the tricuspid annular plane systolic velocity(S’)were measured by conventional echocardiography.Global right ventricular longitudinal deformation parameters were recorded by two-dimensional strain echocardiography from apical 4-chamber views using a four mid-basal RV segments model.The standard deviation of the heart rate-corrected intervals from QRS onset to peak strain for the 4 segments(RV-SD4)was used to quantify right intraventricular dyssynchrony.Results:Compared with control group,the CTD group exhibited significantly lower longitudinal peak systolic strain of mid-basal RV segments(P<0.05),while RV-SD4 was significant longer(P<0.05).Compared with CTD without PAH group,the CTD-PAH group displayed lower longitudinal peak systolic strain of mid-basal RV segments(P<0.05),while RV-SD4 was significant longer(P<0.05).In CTD patients,RV-SD4 were moderately positive correlated with right ventricular longitudinal strain(r=0.586,P<0.001),sPAP(r=0.647,P<0.001),and were moderately negative correlated with TAPSE(r=-0.511,P<0.001),and FAC(r=-0.601,P<0.001).According to the receiver operating characteristic curve analysis,the areas under the curve of RV-SD4 for CTD-PAH patients was 0.777(P<0.001),and the sensitivity and specificity were 67%and 83%,respectively.Conclusion:In CTD-PAH

关 键 词：斑点追踪超声心动图 右室不同步 肺动脉高压 结缔组织病 

分 类 号：R543[医药卫生—心血管疾病]