脑脊液NSE及S-100β蛋白检测在小儿病毒性脑炎、脑膜炎诊治中的价值  

Value of neuron specific enolase and S-100β protein in cerebrospinal fluid in the diagnosis and treatment of children with viral encephalitis and meningitis

作　　者：王华 金剑 应勤来 俞怡雪 Wang Hua;Jin Jian;Ying Qinlai;Yu Yixue(Department of Pediatrics,The Second Hospital of Jiaxing,Jiaxing 314000,Zhejiang Province,China)

机构地区：[1]嘉兴市第二医院儿科,嘉兴314000

出　　处：《中国基层医药》2022年第10期1471-1474,共4页Chinese Journal of Primary Medicine and Pharmacy

基　　金：浙江省嘉兴市公益性研究(自筹经费)计划项目 (2020AD30089)。

摘　　要：目的分析病毒性脑炎、脑膜炎患儿脑脊液中神经元特异性烯醇化酶(NSE)、S-100β蛋白的水平变化及临床意义。方法选取嘉兴市第二医院2018年2月至2020年12月收治的病毒性脑炎、脑膜炎患儿60例为观察组,选取该院同期收治的非中枢神经系统疾病患儿30例为对照组。分析NSE及S-100β蛋白在病毒性脑炎、脑膜炎患儿诊治中的应用价值。结果观察组脑脊液中NSE[(17.683±1.321)μg/L]和S-100β蛋白[(1.755±0.129)μg/L]水平均高于对照组[(5.267±0.907)μg/L、(0.827±0.172)μg/L](t=46.25、28.65,均P<0.001);观察组轻症患儿脑脊液中NSE[(15.219±0.870)μg/L]和S-100β蛋白[(1.456±0.113)μg/L]水平均低于重症患儿[(19.893±1.066)μg/L、(2.014±0.085)μg/L](t=-18.69、-21.32,均P<0.001);观察组急性期脑脊液中NSE[(17.250±1.188)μg/L]和S-100β蛋白[(1.683±0.096)μg/L]水平均高于恢复期[(11.150±0.971)μg/L、(1.147±0.098)μg/L](t=30.79、30.27,均P<0.001)。结论病毒性脑炎、脑膜炎患儿脑脊液中NSE及S-100β蛋白水平可以准确地判断患儿的病情,其对患儿病情的发展及预后判定具有重要的临床应用价值。Objective To investigate the changes and clinical significance of neuron specific enolase(NSE)and S-100βprotein levels in cerebrospinal fluid of children with viral encephalitis and meningitis.Methods Sixty children with viral encephalitis and meningitis admitted to The Second Hospital of Jiaxing from February 2018 to December 2020 were included in the observation group.An additional 30 children without central nervous system diseases who concurrently received treatment in the same hospital were included in the control group.The value of NSE and S-100βprotein levels in the diagnosis and treatment of viral encephalitis and meningitis in chiblren were analyzed.Results NSE and S-100βprotein levels in the observation group were(17.683±1.321)μg/L and(1.755±0.129)μg/L,respectively,which were significantly higher than(5.267±0.907)μg/L and(0.827±0.172)μg/L in the control group(t=46.25,28.65,both P<0.001).NSE and S-100βprotein levels in children with mild viral encephalitis and meningitis were(15.219±0.870)μg/L and(1.456±0.113)μg/L,respectively,which were significantly lower than(19.893±1.066)μg/L and(2.014±0.085)μg/L in children with severe viral encephalitis and meningitis(t=-18.69,-21.32,both P<0.001).In children with viral encephalitis and meningitis,NSE and S-100βprotein levels during the acute phase were(17.250±1.188)μg/L and(1.683±0.096)μg/L,respectively,which were significantly higher than(11.150±0.971)μg/L and(1.147±0.098)μg/L during the convalescence phase(t=30.79,30.27,both P<0.001).Conclusion NSE and S-100βprotein levels in cerebrospinal fluid of children with viral encephalitis and meningitis can help evaluate the severity of viral encephalitis and meningitis in children,providing important clinical application value for judging the development and prognosis of viral encephalitis and meningitis.

关 键 词：神经元特异性烯醇酶 S100蛋白质类 脑脊液 脑炎 病毒性 脑膜炎 儿童 预后 评估 

分 类 号：R725.1[医药卫生—儿科]