基于国家自然科学基金资助项目探讨干燥综合征研究现状  

Investigate the research status of sicca syndrome based on National Natural Science Foundation of China

作　　者：郭子琳 唐晓颇[1] 周新尧[1] 徐浩东 李延婷 张依 GUO Zilin;TANG Xiaopo;ZHOU Xinyao;XU Haodong;LI Yanting;ZHANG Yi(Department of Rheumatology,Guang’anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China)

机构地区：[1]中国中医科学院广安门医院风湿病科,北京100053 [2]中国中医科学院中药研究所,北京100700

出　　处：《中国医药导报》2022年第29期189-192,F0003,共5页China Medical Herald

基　　金：国家自然科学基金青年科学基金项目(81804069);中国中医科学院科技创新工程(CI2021A01510、CI2021A01502);中国中医科学院自主选题研究项目(ZZ11-029);中国中医科学院中央级公益性科研院所基本科研业务费专项资金(ZZ15-XY-PT-11);中国中医科学院基本科研业务费优秀青年科技人才培养专项项目(ZZ15-YQ-023)。

摘　　要：目的 基于国家自然科学基金(NSFC)对干燥综合征(SS)项目的资助情况,分析研究现状及改进方向。方法 搜集NSFC官网及梅斯医学、LetPub、科研者之家数据库2000年1月至2021年12月所有标题、摘要或关键词中包含SS的资助项目,提取项目类型、资助金额、依托单位、负责人、学科代码、关键词、成果转化等信息,运用描述统计方法进行分析。结果 2000-2021年NSFC资助的SS课题88项,包含面上项目、青年科学基金项目、地区科学基金项目和应急管理项目4种类型。2003年SS领域第一次获得NSFC资助,此后资助项目数和经费虽有波动,但总体呈上升趋势。2010-2019年SS资助项目数、金额及成果转化情况均不及类风湿关节炎、系统性红斑狼疮。立项≥3次的11所依托单位中,北京大学的立项数目及经费均居于领先地位。SS课题研究方向广泛,切入角度多样,关键词重复率较低,高频词条为细胞、细胞因子、通路。结论 NSFC资助对SS意义重大,但当前临床需求较大,中医优势未完全体现。后续应注重创新性和多学科交叉,尽快落实指南共识和大数据平台,引领SS临床科研发展。Objective To analyze the research status and improvement direction based on the funding of sicca syndrome(SS) project by National Natural Science Foundation of China(NSFC). Methods From January 2000 to December 2021, all funded projects with SS in their titles, abstracts or keywords were collected from the NSFC website, Mace Medical, LetPub, and Home for researchers. Information such as project type, funding amount, supporting unit, responsible person, discipline code, keywords, and achievement transformation were extracted and analyzed by descriptive statistical method. Results From 2000 to 2021, NSFC funded 88 SS projects, including general projects, youth science funds projects, regional science funds projects, and emergency management projects. In 2003, the SS field received NSFC funding for the first time. Since then, although the number and funding of the projects had fluctuated, the overall trend was on the rise. From 2010 to 2019, the number, amount, and achievement transformation of SS funded projects were lower than those of rheumatoid arthritis and systemic lupus erythematosus. Among the 11 supporting institutions that had approved projects more than three times, Peking University was in the leading position in terms of the number of approved projects and funding. The research direction of SS project was wide, and the angle of entry was diverse.The keywords was repetition rate low, and the high-frequency terms were cell, cytokine, and pathway. Conclusion NSFC funding is of great significance to SS, but the current clinical demand is large, and the advantages of traditional Chinese medicine are not fully reflected. In the future,it should pay attention to innovation and multidisciplinary intersection, implement the guideline consensus and big data platform as soon as possible, and lead the development of SS clinical research.

关 键 词：国家自然科学基金 干燥综合征 研究现状 统计分析 

分 类 号：R59[医药卫生—内科学]