多重致敏儿童变应性鼻炎患者sIgE特征分析  

Analysis of sIgE in polysensitized children with allergic rhinitis

作　　者：鹿伟理 姜涛[1] 李宪华[1] LU Weili;JIANG Tao;LI Xianhua(Department of Otorhinolaryngology,Zhongshan Hospital Affiliated to Dalian University,Dalian 116001,Liaoning,China)

机构地区：[1]大连大学附属中山医院耳鼻咽喉科,辽宁大连116001

出　　处：《山东大学耳鼻喉眼学报》2022年第3期260-265,274,共7页Journal of Otolaryngology and Ophthalmology of Shandong University

摘　　要：目的了解大连地区多重致敏的儿童变应性鼻炎(AR)患者血清特异性IgE(sIgE)特点,为本地区AR精准防控提供参考。方法回顾性分析272例多重致敏的儿童AR患者sIgE结果,按性别、年龄、变应原种类和强度、吸入性和食入性变应原例次和强度进行分组,比较不同组间变应原分布情况。结果应用Pearson相关分析(r=0.587,P=0.035)在所有入组AR儿童中,多重致敏占比与年龄呈正相关,且相关性较高;多重致敏患者变应原种类数量与相应人数之间呈负相关(r=-0.913,P<0.001),且相关性较高。将患儿按年龄段分成3个组,2~5岁组、6~9岁组和10~14岁组,行统计学分析结果显示各组变应原阳性例数与变应原种类呈负相关,且相关性较高。变应原阳性例次及变应原总强度最高的前5位依次为屋尘螨/粉尘螨、艾蒿、猫、蛋清、普通豚草。吸入性和食入性变应原平均强度(t=2.410,P=0.038)差异有统计学意义。按年龄分组,6~9岁组中吸入性与食入性变应原例次差异(t=2.275,P=0.048)及平均强度差异(t=2.361,P=0.035)有统计学意义,10~14岁组中吸入性与食入性变应原平均强度差异有统计学意义(t=3.658,P=0.002)。吸入性变应原中春季、秋季及常年的例次、总强度、平均强度差异均无统计学意义。结论随着年龄增大,接触变应原种类增多,多重致敏患者也随之增多,故应定期复查过敏原。屋尘螨/粉尘螨、艾蒿、猫、蛋清、普通豚草是大连地区多重致敏的AR患儿主要致敏原,应注意重点防控。在6~9岁时应着重关注吸入性变应原致敏情况。Objective To investigate the distribution of serum specific IgE(sIgE)in polysensitized children with allergic rhinitis(AR)in Dalian.Methods Retrospectively analyzed the sIgE results of 272 polysensitized pediatric AR patients,grouped by sex,age,allergen type and intensity,number and intensity of inhaled and ingested allergens,to compare the distribution of allergens between groups.Results Pearson correlation analysis(r=0.587,P=0.035)showed that polysensitization was positively correlated with age in all AR children,and the intensity was higher.Spearman?s correlation analysis(r=-0.913,P<0.001)showed a negative correlation between the number of allergen species and the corresponding number of patients,and the intensity was higher.Based on age,the patients were divided into 3 groups,2-5 years,5-9 years,and 10-14 years.There was a negative correlation between the allergen-positive cases and number of allergen species in each group,and the intensity was higher.The top 5 allergen-positive cases were house dust mite/powder mite,Artemisia,cat,egg white and common ragweed.Based on age,there was a significant difference in the frequency of inhalational and ingestion allergens between the 6-9 years old group(t=2.275,P=0.048).There was significant difference in average strength between inhalation and ingestion allergens(t=2.361,P=0.035).There was a significant difference in average strength between inhalatant and ingestant allergens in the 10-14 years old group(t=3.658,P=0.002).The differences in spring,autumn and year-round among inhalatant allergens were not statistically significant in the number,total intensity and mean intensity.Conclusion As children get older and Increased types of contact allergens,the number of children with polysensitization will also increase.Allergen testing needs to be rechecked regularly.Dermatophagoides farinae/Dermatophagoides farinae,Artemisia argyi,cat,egg white and common ragweed are the main allergens of AR children with polysensitization in Dalian,and attention should be paid to preventi

关 键 词：儿童 变应性鼻炎 变应原 特异性IGE 多重致敏 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]