PI3K/Akt信号通路在HIV感染中的研究进展  

Research progress on the PI3K/Akt signaling pathway in HIV infection

作　　者：马冲 陶庄 王健[2] MA Chong;TAO Zhuang;WANG Jian(Institute of Basic Theory for Chinese Medicine,Chinese Academy of Chinese Medical Sciences,Beijing 100700,China)

机构地区：[1]中国中医科学院中医基础理论研究所,北京100700 [2]中国中医科学院中医药防治艾滋病中心,北京100700 [3]安徽中医药大学第一附属医院脑制,合肥130031

出　　处：《传染病信息》2022年第5期394-398,共5页Infectious Disease Information

基　　金：“十三五”国家科技重大专项(2017ZX10205501)。

摘　　要：磷脂酰肌醇3-激酶(phosphoinositide 3-kinase, PI3K)/蛋白激酶B(protein kinase B, PKB,普遍写作Akt)信号通路参与调控多种细胞功能,与多种疾病的发生密切相关。PI3K/Akt信号通路在HIV感染过程中也发挥重要作用,包括调节T细胞、线粒体功能,促进HIV复制,再激活潜伏HIV以及维持病毒储存库。因此,探索PI3K/Akt信号通路在HIV感染中的作用机制具有重要意义,针对PI3K/Akt的靶向治疗可能在抗HIV中发挥关键作用。本文对PI3K/Akt信号通路与HIV感染的相关研究进行综述,旨在为抗HIV的治疗提供新的思路与靶点。PI3K/Akt signaling pathway is involved in the regulation of cells function and is closely related to the occurrence of various diseases. Furthermore, PI3K/Akt signaling pathway plays a vital role in HIV infection, including regulating T cells and mitochondrial function, promoting HIV replication, reactivating latent HIV, and maintaining virus reservoirs. Therefore, it is significant to explore the mechanism of PI3K/Akt signaling pathway in HIV infection. PI3K/Akt targeted therapy may play a key role in anti-HIV therapy. This review will integrate the correlative researches about PI3K/Akt signaling pathway in HIV infection aiming to provide new ideas and targets for the treatment of HIV infection.

关 键 词：PI3K/AKT HIV 病毒储存库 T细胞 线粒体 HIV复制 HIV进入 免疫调节 

分 类 号：R51[医药卫生—内科学]