抗鸡球虫病基因重组疫苗的研究进展  

Progress on Gene Recombinant Vaccines against Avian Coccidiosis

作　　者：邱茜茜 戚南山 李易 李娟 廖申权 吕敏娜 蔡海明 林栩慧 胡俊菁 肖文婉 张健騑 张旭 孙铭飞 QIU Xi-xi;QI Nan-shan;LI Yi;LI Juan;LIAO Shen-quan;Lü Min-na;CAI Hai-ming;LIN Xu-hui;HU Jun-jing;XIAO Wen-wan;ZHANG Jian-fei;ZHANG Xu;SUN Ming-fei(Foshan University,Foshan,Guangdong,528231,China;Institute of Animal Health,Guangdong Academy of Agricultural Sciences,Maoming Branch,Guangdong Laboratory for Lingnan Modern Agriculture,Scientific Observation and Experiment Station of Veterinary Drugs and Diagnostic Techniques of Guangdong Province,Ministry of Agriculture,Key Laboratory of Livestock Disease Prevention of Guangdong Province,Guangzhou,Guangdong,510640,China)

机构地区：[1]佛山科学技术学院,广东佛山528231 [2]广东省农业科学院动物卫生研究所,岭南现代农业科学与技术广东省实验室茂名分中心,农业农村部兽用药物与诊断技术广东科学观测实验站,广东省畜禽疫病防治研究重点实验室,广东广州510640

出　　处：《动物医学进展》2022年第11期74-79,共6页Progress In Veterinary Medicine

基　　金：广东省自然科学基金项目(2021A1515012401,2021A1515010521);广东省农业科学院科技创新专家制项目(202110TD,R2020PY-JC001,R2021PY-QY007)。

摘　　要：鸡球虫病是由艾美耳属球虫引起的鸡的一种肠道原虫病,对养鸡业的发展危害严重。目前主要依靠药物和活卵囊疫苗来防治鸡球虫病,但药物防治存在耐药性和药物残留等问题,而免疫活卵囊疫苗带来的肠道损伤等问题使养鸡业在控制鸡球虫病方面面临巨大挑战,新型防控策略亟待开发。基因重组疫苗生产工艺简单、稳定、安全、高效,在分子生物学技术高速发展的当下,其将成为鸡球虫病防治的新型手段。目前对基因重组疫苗的研究日益增多,但缺乏系统的抗鸡球虫病基因重组疫苗的综述分析。鉴于此,论文从当前抗鸡球虫病措施、鸡球虫病基因重组疫苗候选因子及影响因素等方面对抗鸡球虫病基因重组疫苗的研究进展进行综述,以期为抗鸡球虫病基因重组疫苗的研发提供参考。Avian coccidiosis is an important intestinal protozoan disease caused by various Eimeria species,which seriously caused significant economic losses of chicken industry.Anticoccidials and live oocyst vaccines are the two main approaches to prevent and control avian coccidiosis.However,anticoccidial drugs cause drug resistances as well as serious drug residues,and live oocyst vaccines cause intestinal damage make the chicken industry facing agreat challenge in the control of avian coccidiosis.In comparision,recombinant vaccine is easy to administration,and is also stable,safe and efficient,thus has become a new control strategy against avian coccidiosis.At present,there are a lot of researches on gene recombinant vaccines,but no systematic review and analysis about controlling avian coccidiosis.In this paper,the research progress on gene recombinant vaccines of avian coccidiosis was reviewed from current anticoccidiosis measures including the aspects of vaccine candidates and influencing factors,in order to provide insightful knowledge for the research and development of recombinant vaccine against avian coccidiosis in the future.

关 键 词：鸡球虫 抗鸡球虫病措施 基因重组疫苗 疫苗候选分子 

分 类 号：S859.795[农业科学—临床兽医学] S858.31[农业科学—兽医学]