短暂性脑缺血发作患者血清RBP4、NF-κB表达与颈动脉斑块稳定性的关系  被引量:1

Relationship between the expression of serum RBP4 and NF-κB and the stability of carotid artery plaque in patients with transient ischemic attack

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作  者:高蓓 刘菲 薛金娥 赵海红 GAO Bei;LIU Fei;XUE Jin'e;ZHAO Hai-hong(Outpatient Office Department of Nursing,Xi'an 710054,Shaanxi,CHINA;Outpatient Office,Shaanxi Xin'an Central Hospital,Xi'an 710054,Shaanxi,CHINA)

机构地区:[1]陕西省新安中心医院门诊办,陕西西安710054 [2]陕西省新安中心医院护理部,陕西西安710054

出  处:《海南医学》2022年第20期2599-2602,共4页Hainan Medical Journal

摘  要:目的检测短暂性脑缺血发作(TIA)患者血清中视黄醇结合蛋白4(RBP4)、核因子kappa B(NF-κB)的表达水平,并分析其与颈动脉斑块稳定性的关系。方法选取2019年1月至2021年5月陕西省新安中心医院收治的80例TIA合并颈动脉斑块患者为研究对象,根据颈动脉斑块的稳定性分为斑块稳定组(n=30)和斑块不稳定组(n=50)。同期随机选择于本院体检且与患者一般资料匹配的健康人群66例为对照组。利用酶联免疫吸附法(ELISA)检测血清RBP4、NF-κB表达水平,采用Pearson法分析两者的相关性;检测并比较所有受检者的甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、D二聚体(DD)、同型半胱氨酸(Hcy)、尿酸(UA)水平,采用Pearson法分析各指标与血清RBP4、NF-κB水平的相关性;利用受试者工作特征曲线(ROC)分析RBP4、NF-κB水平诊断TIA患者颈动脉斑块不稳定的临床价值。结果斑块不稳定组和斑块稳定组患者血清RBP4[(38.05±4.71)mg/L、(33.22±4.06)mg/L]、NF-κB[(21.75±6.14)μg/L、(17.65±5.22)μg/L]水平与对照组比较[RBP4(22.71±3.44)mg/L、NF-κB(15.02±4.25)μg/L]均显著升高,且斑块不稳定组高于斑块稳定组,差异有统计学意义(P<0.05);TIA合并颈动脉斑块患者的血清BP4、NF-κB水平表达呈明显正相关(r=0.289,P<0.05);TIA合并颈动脉斑块患者血清RBP4、NF-κB水平均与TG、DD、Hcy、UA呈正相关,差异有统计学意义(P<0.05);经ROC分析结果显示,血清RBP4、NF-κB水平评估TIA合并不稳定颈动脉斑块的曲线下面积(AUC)分别为0.822、0.795,对应的敏感性分别为70.00%、72.00%,特异性分别为90.00%、83.33%。两者联合评估TIA患者合并不稳定颈动脉斑块的AUC为0.885,敏感性为88.00%,特异性为80.00%。结论TIA合并颈动脉斑块患者血清中RBP4、NF-κB水平均呈高表达,两者呈正相关,且对合并颈动脉斑块不稳定患者具有较高的诊断和预测价值,有助�Objective To explore the levels of serum retinol binding protein 4(RBP4)and nuclear factor kappa B(NF-κB)in patients with transient ischemic attack(TIA),and to analyze their relationship with the stability of carotid artery plaque.Methods A total of 80 patients with TIA complicated with carotid plaques who were admitted to Shaanxi Xin'an Central Hospital from January 2019 to May 2021 were selected as the research objects,and they were divided into stable plaque group(n=30)and unstable plaque group(n=50)according to the stability of carotid plaques.During the same period,66 healthy people who underwent physical examination in the hospital and had matched general data of the patients were randomly selected as the control group.The expression levels of serum RBP4 and NF-κB were detected by enzyme-linked immunosorbent assay(ELISA),and the Pearson method was used to analyze the correlation between them.The triglycerides(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),D-dimer(DD),homocysteine(Hcy),and uric acid(UA)levels were detected and compared.Pearson method was used to analyze the correlation between each index and serum RBP4 and NF-κB levels.The clinical value of RBP4 and NF-κB levels in the diagnosis of unstable carotid plaque in patients with TIA was analyzed with receiver operating characteristic curve(ROC).Results The levels of serum RBP4 were(38.05±4.71)mg/L in unstable plaque group and(33.22±4.06)mg/L in stable plaque group,and NF-κB were(21.75±6.14)μg/L,(17.65±5.22)μg/L,respectively,which were significantly increased compared with RBP4(22.71±3.44)mg/L and NF-κB(15.02±4.25)μg/L in the control group;the levels in unstable plaque group were significantly higher than those in stable plaque group;the differences were statistically significant(P<0.05).The expression of RBP4 and NF-κB in serum of patients with TIA combined with carotid plaque was positively correlated(r=0.289,P<0.05);the levels of serum RBP4 and NF-κB were positivel

关 键 词:短暂性脑缺血发作 颈动脉斑块稳定性 视黄醇结合蛋白4 核因子kappa B 超声 相关性 

分 类 号:R743.31[医药卫生—神经病学与精神病学]

 

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