江苏省苏锡常地区心血管健康行为和因素对绝经后女性骨质疏松的影响  

Effects of cardiovascular health behaviors and factors on postmenopausal osteoporosis in Suxichang area of Jiangsu province

作　　者：贾冰[1] 沈振海 李红卫 张萍 袁芳岑 陆昀 Jia Bing;Shen Zhenhai;Li Hongwei;Zhang Ping;Yuan Fangcen;Lu Yun(Department of Endocrine,Affiliated Hospital of Jiangsu Institute of Nuclear Medicine,Wuxi,214063,China;Department of Cardiovascular Medicine,Jiangsu Provincial People's Hospital Group Taihu Sanatorium of Jiangsu Province,Wuxi,214086,China;Department of Rehabilitation,Wuxi People's Hospital Affiliated to Nanjing Medical University,Wuxi,214023,China)

机构地区：[1]江苏省原子医学研究所附属江原医院内分泌科,无锡214063 [2]江苏省人民医院集团江苏省太湖疗养院心内科,无锡214086 [3]南京医科大学附属无锡人民医院康复医学科,无锡214023

出　　处：《中华老年医学杂志》2022年第10期1215-1219,共5页Chinese Journal of Geriatrics

基　　金：江苏省医学重点学科(共建)项目(IDXKC2016011);无锡市科技研发资助项目(MB41S1701)。

摘　　要：目的探讨江苏省苏锡常地区绝经后女性心血管健康行为和因素与骨质疏松的相关性。方法采用横断面研究,抽取2019年3月至2020年6月在江苏省太湖疗养院健康体检的绝经后女性2423例,收集受检者心血管健康行为(体质指数、运动、饮食和吸烟)、心血管健康因素(血压、空腹血糖和总胆固醇)及骨密度检测结果,7个因子按照定义分为理想、一般和差。按骨密度水平分为骨量正常组1305例、骨量减少组828例和骨质疏松组290例。结果骨质疏松组与骨量正常组人群比较,年龄、空腹血糖、收缩压、舒张压、总胆固醇、运动情况差异有统计学意义(均P<0.05)。随理想心血管健康行为和因素个数的增加,受检者骨质疏松比例逐渐降低(P<0.05)。Logistic回归分析结果显示,年龄、总胆固醇和空腹血糖是骨质疏松的危险因素,运动是骨质疏松的保护因素。当年龄、总胆固醇、体质指数和空腹血糖每增加1个单位时,受检者骨密度降低1个等级的OR值分别为1.17、1.25、0.92和1.23(均P<0.05);运动每降低1个等级,骨密度降低1个等级的OR值为0.58(P<0.05)。结论绝经后女性应积极调控总胆固醇和空腹血糖水平,适当保持体重和规律运动有助于骨质疏松的防治。Objective To explore the relationship of cardiovascular health behavior and factors with development of bone mass loss and postmenopausal osteoporosis in Suxichang area of Jiangsu province.Methods In the across sectional study,a total of 2423 postmenopausal women receiving health check-up from March 2019 to June 2020 in our hospital were enrolled.The seven variable factors included cardiovascular health behavior(body mass index,exercise,healthy diet and smoking state)and cardiovascular health-influencing factors(blood pressure,fasting blood glucose and total cholesterol).The information of the seven factors and bone mineral density were recorded.The seven factors were classified as ideal,average and poor,according to the level of bone mineral density.All individuals were divided into three groups:normal bone mass(n=1305),osteopenia(n=290)and osteoporosis(n=828).Results There were statistically significant differences in age,fasting blood glucose,systolic blood pressure,diastolic blood pressure,total cholesterol and exercise between osteoporosis and normal bone mass group(P<0.05).As the number of ideal cardiovascular health behaviors and factors increased,the proportion of bone mass loss and osteoporosis gradually decreased(P<0.05).Multiple logistic regression analysis showed that ageing,increased total cholesterol and fasting blood glucose levels were the independent risk factors of osteoporosis.The exercise and normal body mass index were the protective factors for osteoporosis.For each 1 unit increment in age,total cholesterol,body mass index and fasting blood glucose,the OR values for bone mineral density decrement by 1 grade were 1.17,1.25,0.92 and 1.23,respectively(all P<0.05).The OR value for bone mineral density decrement by 1 grade was 0.58(P<0.05)when exercise decreased by 1 grade.Conclusions Postmenopausal women should positively control the levels of total cholesterol and fasting blood glucose,maintain reasonable body weight and conduct regular exercise,which are conductive to the prevention and treatm

关 键 词：健康行为 骨质疏松 绝经后 

分 类 号：R54[医药卫生—心血管疾病] R580[医药卫生—内科学]