外泌体miRNA在糖尿病膀胱中的作用  

Research advances on exosome miRNA in diabetic cystopathy

作　　者：薛博 孙李斌 吴波 田锦明 王东文[1,3] Xue Bo;Sun Libin;Wu Bo;Tian Jinming;Wang Dongwen(Shanxi Medical University,Taiyuan 030001,China;Department of Urology,First Hospital of Shanri Medical University,Taiyuan 03000l,China;Department of Urology,National Cancer Center National Clinical Research Center for Cancer Cancer Hospital&Shenzhen Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Shenzhen 518116,China)

机构地区：[1]山西医科大学,太原030001 [2]山西医科大学第一医院泌尿外科,太原030001 [3]国家癌症中心,国家肿瘤临床医学研究中心,中国医学科学院北京协和医学院肿瘤医院深圳医院泌尿外科,深圳518116

出　　处：《中华老年医学杂志》2022年第10期1254-1258,共5页Chinese Journal of Geriatrics

基　　金：国家自然基金(81970662,81800668)。

摘　　要：糖尿病膀胱(DCP)发病机制复杂多样,早期诊断标准缺乏特异性与敏感性指标,亟需更多研究指导临床诊治。外泌体是携带蛋白质和核酸等各种生物信息的膜性囊泡,对各组织器官间的交流有着重要意义。本综述就外泌体miRNA在DCP发病机制中的潜在作用和治疗上的应用进行探讨,为DCP的诊治提供新的思路。The pathogenesis of diabetic cystopathy(DCP)is complex and early diagnosis is hindered by a lack of specific and sensitive criteria and more research is needed to establish guidelines for its clinical diagnosis and treatment.Exosomes are membrane vesicles carrying various biological information such as proteins and nucleic acids,which are critical for communication between different tissues and organs.This review discusses the potential role of exosome miRNA in the pathogenesis of DCP and its application in therapy,aiming to provide new insight into the diagnosis and treatment of DCP.

关 键 词：糖尿病 排尿障碍 外泌体 

分 类 号：R587.2[医药卫生—内分泌] R694[医药卫生—内科学]