补肾调肝方治疗肝郁肾虚型绝经后骨质疏松症疗效观察  

Observation of Curative Efficacy of Bushen Tiaogan Formula(补肾调肝方)in Treatmentof Postmenopausal Osteoporosis of Liver Stagnation and Kidney Deficiency Type

作　　者：安镇南 宋明熹 吴春飞 范帅 钟贤兴 高丰禾 梁祖建 AN Zhennan;SONG Mingxi;WU Chunfei;FAN Shuai;ZHONG Xianxing;GAO Fenghe;LIANG Zujian(The Third College of Clinical Medicine,Guangzhou University of Chinese Medicine,Guangzhou 510405,China;Department of Orthopedics,Foshan Hospital of Traditional Chinese Medicine,Foshan 528051,China;Department of Osteoporosis,The Third Affiliated Hospital,Guangzhou University of Chinese Medicine,Guangzhou 510375,China)

机构地区：[1]广州中医药大学第三临床医学院,广东广州510405 [2]佛山市中医院骨科,广东佛山528051 [3]广州中医药大学第三附属医院骨质疏松科,广东广州510375

出　　处：《山东中医杂志》2022年第11期1176-1179,共4页Shandong Journal of Traditional Chinese Medicine

基　　金：广东省自然科学基金项目(编号:2021A1515011469);广东省中医药局科研项目(编号:20211211,20201171)。

摘　　要：目的:观察补肾调肝方治疗肝郁肾虚型绝经后骨质疏松症的临床疗效。方法:选取肝郁肾虚型绝经后骨质疏松症患者60例,以随机数字表法分为观察组和对照组各30例(研究中观察组脱落1例,余29例),对照组采用常规抗骨质疏松治疗方案,观察组加用补肾调肝方治疗,治疗周期为12周。比较两组腰背痛评分(McGill疼痛问卷评分法)、肢体活动状况(SPPB)评分、汉密尔顿焦虑量表(HAMA)评分、汉密尔顿抑郁量表(HAMD)评分、Ⅰ型胶原氨基端延长肽(P1NP)水平及骨密度,评价临床疗效。结果:治疗后,两组患者各观察指标均较治疗前改善(P<0.05),且观察组McGill、HAMA、HAMD评分及P1NP水平均低于对照组,SPPB评分及骨密度高于对照组(P<0.05);观察组总有效率82.76%,对照组60.00%,观察组疗效优于对照组(P<0.05)。结论:补肾调肝方治疗肝郁肾虚型绝经后骨质疏松症能有效减轻患者疼痛,提高肢体活动功能,缓解焦虑抑郁状态,改善骨代谢,提高骨密度。Objective:To observe the clinical curative efficacy of Bushen Tiaoan Formula(补肾调肝方)on postmenopausal osteoporosis of liver stagnation and kidney deficiency type.Methods:Sixty patients with postmenopausal osteoporosis of liver stagnation and kidney deficiency type were divided into observation group and control group with random number table method,30 patients in each group(1 drop-out case in the observation group).The control group were given routine treatment for osteoporosis,and the observation group was further treated with Bushen Tiaogan Formula.One treatment course lasted 12 weeks.Back pain score(McGill Pain Questionnaire),Short Physical Performance Battery(SPPB)score,Hamilton anxiety scale(HAMA)score,Hamilton depression scale(HAMD)score,procollagen typeⅠN-terminal propeptide(P1NP)and bone density were tested to evaluate clinical efficacy.Results:After the treatment,both groups were improved on the all indexes(P<0.05),McGill,HAMA and HAMD scores and P1NP levels were lower in the observation group than those in the control group,while SPPB score and bone density were higher in the observation group than those in the control group(P<0.05).The total effectiveness rate in the observation group was 82.76%,and that in the control group was 60.00%.The observation group was better than the control group on the clinical efficacy(P<0.05).Conclusion:Bushen Tiaogan Formula is effective in reducing pain,improving limb function,alleviating anxiety and depression,improving bone metabolism and bone density in treating postmenopausal osteoporosis of liver stagnation and kidney deficiency type.

关 键 词：补肾调肝方 绝经后骨质疏松症 肝郁肾虚 骨代谢 骨密度 焦虑 抑郁 

分 类 号：R259.895[医药卫生—中西医结合]