非哺乳期乳腺炎中医证型与自身免疫功能的相关性研究  

Correlation between Traditional Chinese Medicine Syndrome Types and Autoimmune Function of Patients with Non-lactation Mastitis

作　　者：谢璐 冯佳梅[1] 吴雪卿[1] 万华[1] XIE Lu;FENG Jiamei;WU Xueqing;WAN Hua(Department of Mammary Gland,Shuguang Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200021,China)

机构地区：[1]上海中医药大学附属曙光医院乳腺科,上海200021

出　　处：《山东中医杂志》2022年第11期1186-1191,共6页Shandong Journal of Traditional Chinese Medicine

基　　金：上海市科学技术委员会科研计划项目(编号:19401934000)。

摘　　要：目的:探讨非哺乳期乳腺炎中医证型与自身免疫功能的相关性。方法:收集符合肝经郁热证和痰湿蕴热证的非哺乳期乳腺炎患者各32例,采集并记录临床资料,分析比较两种证型患者的血清免疫指标水平。结果:相较于肝经郁热证患者,痰湿蕴热证患者乳房疼痛明显(P=0.004);两种证型患者细胞免疫功能紊乱均表现为CD3^(+)、CD4^(+)、CD8^(+)、CD8^(+)CD28^(+)T细胞表达的上调及CD4^(+)CD25^(+)T细胞表达的下调,其中相较于肝经郁热证患者,痰湿蕴热证患者CD3^(+)T细胞表达异常以升高为主(P=0.024),占12.5%(4/32);两种证型患者体液免疫功能紊乱表现为免疫球蛋白(Ig)G、IgA、IgE、IgM、补体成分4(C4)、50%溶血补体量(CH50)的上调和补体成分3(C3)的下降,其中痰湿蕴热证患者IgG表达较肝经郁热证患者明显(P<0.001)。结论:非哺乳期乳腺炎患者的中医证型与免疫表达状态存在一定相关性,不同证型患者的免疫功能紊乱状态不同,相较于肝经郁热证,痰湿蕴热证患者的免疫表达更为强烈。Objective:To investigate the correlation between the traditional Chinese medicine(TCM)syndromes and immune function of patients with non-lactation mastitis(NLM).Methods:Thirty two patients with NLM of stagnated heat in liver channel syndrome and 32 patients with NLM of accumulated heat of phlegm dampness syndrome were included.Clinical information were collected and recorded,and the serum immunity indexes of both syndromes were analyzed and compared.Results:Compared with patients of stagnated heat of liver channel syndrome,patients with accumulated heat of phlegm dampness showed obvious breast pain(P=0.004).The cellular immune dysfunction of patients was characterized by up-regulation of CD3^(+),CD4^(+),CD8^(+),CD8^(+)CD28^(+)T cells and down-regulation of CD4^(+)CD25^(+)T cells.The expression of CD3^(+)T cells in patients with accumulated heat of phlegm dampness syndrome mainly increased compared with that in patients with stagnated heat of liver channel syndrome(P=0.024),accounting for 12.5%(4/32).The humoral immune dysfunction of patients showed the up-regulation of immunoglobulin(Ig)G,IgA,IgE,IgM,complement(C)4,50%hemolysis of complement(CH50)and the decrease of C3.The expression of IgG in patients of accumulated heat of phlegm dampness syndrome was significantly higher than that of patients with stagnated heat of liver channel syndrome(P<0.001).Conclusions:TCM syndrome types of NLM patients are related to immune expression states to a certain degree.Patients of different syndromes types showed different states of immunity disorder.Compared with patients of stagnated heat in liver channel syndrome,the patients of accumulated heat of phlegm dampness syndrome showed more vigorous immune expression.

关 键 词：非哺乳期乳腺炎 肝经郁热 痰湿蕴热 细胞免疫 体液免疫 T淋巴细胞 免疫球蛋白 补体 

分 类 号：R269.558[医药卫生—中西医结合]