催化不对称合成手性氧化吲哚螺五元环衍生物的研究进展  

Advances in catalytic asymmetric synthesis of chiral spirooxindoles fused with a five-membered ring

作　　者：黄磊 徐佳琦 许正伟 李浩[1] 何燕 吴琼 Huang Lei;Xu Jiaqi;Xu Zhengwei;Li Hao;He Yan;Wu Qiong(Xuzhou University of Technology,Xuzhou 221018,China)

机构地区：[1]徐州工程学院,江苏徐州221018

出　　处：《现代盐化工》2022年第5期1-3,共3页Modern Salt and Chemical Industry

基　　金：徐州工程学院大学生创新创业训练计划项目“吲哚类抗癌药物分子的高效构建”(xcx2021005)。

摘　　要：手性氧化吲哚螺五元环衍生物广泛存在于天然产物及药物分子中,在医药领域应用广泛。因此,高对映选择性地实现手性氧化吲哚螺五元环骨架的构建是有机化学领域的研究热点之一。综述了近年来通过催化不对称合成策略构建手性氧化吲哚螺五元杂环骨架的研究进展,希望能为相关领域的研究工作者提供有价值的参考。Chiral spirooxindoles fused with a five-membered ring are widely found in natural products and drug molecules,and are widely used in the pharmaceutical field.Therefore,the construction of chiral spirooxindole skeleton fused with a five-membered ring with the high enantioselectivity is one of the hot research topics in the field of organic chemistry.The recent research progress of the construction of the chiral ospirooxindoles fused with a five-membered ring through the catalytic asymmetric synthetic strategy is reviewed,hoping to provide a valuable reference for researchers in related fields.

关 键 词：手性氧化吲哚螺环 五元环 催化不对称 

分 类 号：O626[理学—有机化学]