对于口服达泊西汀无疗效的原发性早泄患者的血浆5-羟色胺浓度变化的临床初步研究  

A preliminary clinical study on the changes of plasma 5-HT concentration in patients with primary premature ejaculation

作　　者：朱科 黄翔[2] 李建[1] 周建 白天[1] 曹波 文刚 唐菁菁 ZHU Ke;HUANG Xiang;LI Jian;ZHOU Jian;BAI Tian;CAO Bo;WEN Gang;TANG Jingjing(Urology Departmen,Chengdu Jinniu District People's Hospita,Chengdu,Sichuan 610036,China;Urology Departmen,Sichuan Provincial People's Hospital,Chengdu,Sichuan 610072,China)

机构地区：[1]成都市金牛区人民医院泌尿外科,四川成都610036 [2]四川省人民医院泌尿外科,四川成都610072

出　　处：《国际检验医学杂志》2022年第S02期45-48,共4页International Journal of Laboratory Medicine

摘　　要：目的了解对达泊西汀治疗无效的原发性早泄患者治疗前后血浆5-羟色胺浓度的变化及其与治疗有效患者的差异。方法选择成都市金牛区人民医院门诊符合阴道内射精潜伏时间(IELT)定义的原发性早泄患者,年龄在18~65岁之间,所有入选患者性生活前4 d每晚口服达泊西汀30 mg(4 d可达稳定血药浓度),4 d后则按需在性生活前1~3 h服药。记录服药后3次性生活情况后,予以随访。在服药前,记录IELT及早泄简表(PEP)问卷;并在服药前予以抽血离心冻存。连续服药4 d后,以同样的方法提取患者血浆样本并冻存。记录3次性生活情况后,通过筛选问卷调查,将对口服达泊西汀治疗反馈为“无效”的患者作为本研究实验组A组(患者反馈治疗后IELT无明显增加,PEP各项得分无明显提升),共45例。将对达泊西汀治疗反馈为“有效”的患者作为本研究的对照组B组(患者反馈治疗后IELT明显增加,PEP各项得分明显提升),共75例。运用统计分析比较两组在治疗前5-羟色胺浓度是否具有差异,在治疗后两组5-羟色胺的浓度是否发生改变,且改变是否具有差异。结果两组在治疗前5-羟色胺的浓度差异无统计学意义(P>0.05),在治疗后,A组血浆5-羟色胺浓度未见明显提升(P>0.05);B组血浆5-羟色胺浓度未见明显提升治疗后5-羟色胺浓度明显增加并明显高于A组,差异有统计学意义(P<0.001)。结论对于达泊西汀治疗无效的患者,其治疗前后血浆5-羟色胺浓度未发生明显改变,提示其他可能原因导致了早泄的发生,早泄的治疗还需要结合其他治疗手段综合治疗。Objective To investigate the changes of plasma 5-HT concentration before and after treatment in patients with primary premature ejaculation who had failed dapoxetine treatment and the difference between them and those who had been treated effectively.Methods Select the patients with primary premature ejacu-lation who meet the definition of vaginal ejaculation latency(IELT)in the outpatient department of Chengdu Jinniu District People's Hospital,aged between 18 and 65 years old.All selected patients took dapoxetine 30mg orally 4 days before sexual life and took dapoxetine 1 to 3 hours before sexual life as needed 4 days lat-er.Three times of sexual life were recorded and followed up.IELT and PEP questionnaire were recorded be-fore medication.Blood samples were drawn and centrifuged before medication.After 4 consecutive days of medication,plasma samples were extracted and frozen in the same way.After recording three times of sexual life,45 patients who reported that oral dapoxetine treatment was"ineffective"were selected as experimental group A(patients reported that IELT and PEP scores did not increase significantly after treatment).Patients who reported that dapoxetine treatment was"effective"were selected as the control group B(IELT and PEP scores were significantly increased after patients reported dapoxetine treatment),including 75 patients.Statis-tical analysis was conducted to compare whether there was any difference in 5-HT concentration between the two groups before treatment and whether there was any change in 5-HT concentration between the two groups after treatment,and whether there was any difference in the change.Results There was no significant difference in 5-HT concentration between the two groups before treatment(P>0.05),and no significant in-crease in plasma 5-HT concentration in group A after treatment(P>0.05).The plasma 5-HT concentration in group B was not significantly increased after treatment and was significantly higher than that in group A(P<0.001).Conclusion For patients who failed dapox

关 键 词：原发性早泄 达泊西汀 血浆5-羟色胺浓度 

分 类 号：R698[医药卫生—泌尿科学]