Hcy、FA联合检测对妊娠期高血压疾病的临床意义  

The clinical significance of the combined detection of Hcy and FA in hypertensive disorders of pregnancy

作　　者：甄斐斐 魏涛[1] 宋伟[1] ZHEN Feifei;WEI Tao;SONG Wei(Department of Obstetrics and Gynecology,General Hospital of Shanxi Taiyuan Iron&Steel Co.,Ltd.,Taiyuan,Shanxi 030008,China)

机构地区：[1]山西太原钢铁(集团)有限公司总医院妇产科,山西太原030008

出　　处：《国际检验医学杂志》2022年第S02期89-92,共4页International Journal of Laboratory Medicine

摘　　要：目的分析同型半胱氨酸(Hcy)、叶酸(FA)联合检测用于妊娠期高血压(HDP)的价值。方法选择2018年7月至2020年9月于该院收治的85例HDP孕妇作为观察组,根据HDP疾病分类标准将其分为3组,分别为HDP组(21例)、轻度子痫前期组(34例)及重度子痫前期组(30例),另将同期于该院进行产检的50例健康孕妇作为对照组。比较两组血清Hcy、FA水平,采用受试者工作特征(ROC)曲线分析Hcy、FA联合检测的诊断效能,孕期HDP严重程度同血清Hcy、FA水平的关系行Spearman相关性分析,Logistic回归分析HDP不良妊娠结局的影响因素。结果观察组血清Hcy水平显著高于对照组,FA水平显著低于对照组,差异有统计学意义(P<0.05);重度子痫前期组血清Hcy水平显著高于HDP组和轻度子痫前期组,差异有统计学意义(P<0.05),HDP组血清FA水平显著高于轻度子痫前期组和重度子痫前期组,差异有统计学意义(P<0.05);Hcy、FA联合诊断HDP的灵敏度、特异度分别为72.94、80.00;HDP严重程度与血清Hcy水平呈正相关(r=0.581,P<0.05),同FA水平呈负相关(r=-0.503,P<0.05)。同不良妊娠结局相比,妊娠结局良好组的血清Hcy水平降低,FA水平升高(P<0.05),血清Hcy、FA均为HDP孕妇不良妊娠结局的独立危险因素(P<0.05)。结论Hcy、FA联合检测可在一定程度上判断HDP疾病的严重程度,用于诊断HDP疾病效能较好,HDP严重程度与血清Hcy水平呈正相关,同FA水平呈负相关,且可作为不良妊娠结局的独立危险因素,高水平的Hcy、低水平的FA预示着HDP孕妇的不良妊娠结局。Objective To analyze the value of the combined detection of homocysteine(Hcy)and folic acid(FA)in hypertensive disorders of pregnancy(HDP).Methods Eighty five cases of HDP pregnant women admitted to the hospital from July 2018 to September 2020 were selected as the observation group.There were divided into three groups according to the HDP classification criteria,including the gestational hypertension group(21),the mild preeclampsia group(34)and the severe preeclampsia group(30).50 cases of healthy pregnant women who were examined in the hospital during the same period were selected as the control group.The levels of serum Hcy and FA were compared between the two groups.The diagnostic efficiency of the combined detection of Hcy and FA was analyzed by ROC curve.Spearman correlation analysis was performed for the relationship between the severity of HDP during pregnancy and the levels of serum Hcy and FA.Logistic regression was used to analyze the influencing factors of adverse pregnancy outcomes in HDP.Results Serum Hcy levels in the observation group were significantly higher than those in the control group,and FA level was significantly lower than that in the control group,the difference was statistically significant(P<0.05);Serum Hcy levels in the sever preeclampsia group were significantly higher than those in the gestational hypertension group and the mild preeclampsia group,the difference was statistically significant(P<0.05).The serum FA level in the gestational hypertension group was significantly higher than that in the mild preeclampsia and the sever preeclampsia group,the difference was statistically significant(P<0.05);The sensitivity and specificity of Hcy+FA in the diagnosis of HDP were 72.94 and 80.00,respectively;The severity of HDP was positively correlated with serum Hcy levels,and negatively correlated with FA levels,the difference was statistically significant(P<0.05).Compared with adverse pregnancy outcomes,serum Hcy levels increased and FA levels decreased in the group with good pregnancy out

关 键 词：同型半胱氨酸 叶酸 妊娠期高血压 

分 类 号：R714.256[医药卫生—妇产科学]