铁载体不动杆菌素及相关新型抗感染药物的研究进展  

Research progress of siderophore acinetobacter and related new anti-infective drugs

作　　者：王珊(综述) 王崇刚(审校)[1] WANG Shan;FENG Yuan;WANG Chonggang(Department of Respiratory and Critical Care Medicine,the Second Hospital of Shanxi Medical University,Taiyuan,Shanxi 030000,China)

机构地区：[1]山西医科大学第二医院感染学疾病科,山西太原030000

出　　处：《国际检验医学杂志》2022年第S02期147-150,共4页International Journal of Laboratory Medicine

摘　　要：铁离子是大多数生物生存必不可少的元素之一,生物体内很多酶催化反应都需要铁离子的参与。鲍曼不动杆菌为获取铁元素,进化出了一系列能够螯合并摄取铁的铁载体。本文就鲍曼不动杆菌的铁载体不动杆菌素生物合成、摄取机制以及基于此研制的新型抗感染药物进行综述,为克服鲍曼不动杆菌的耐药性提供新的治疗策略。Iron ion is one of the essential elements for the survival of most organisms.Many enzymatic reactions in the body of organisms require the participation of iron ion.In order to obtain iron,Acinetobacter baumannii has evolved a series of siderophore that can chelate and ingest iron.In this review,the biosynthesis and uptake mechanism of siderophore acinetobacter baumannii and the development of new anti-infective drugs based on the siderophore acinetobacter baumannii are reviewed,so as to provide a new treatment strategy for overcoming the resistance of Acinetobacter baumannii.

关 键 词：鲍曼不动杆菌 毒力 铁吸收 铁载体 不动杆菌素 

分 类 号：Q93[生物学—微生物学]