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作 者:朱晶 张睿[1] 赵媛 李炀 赵昱 ZHU Jing;ZHANG Rui;ZHAO Yuan;LI Yang;ZHAO Yu(Department of Otorhinolaryngology&Head and Neck Surgery,Xi'an Childrens's Hospital,Xi'an 710003,Shaanxi,China)
机构地区:[1]西安市儿童医院耳鼻咽喉头颈外科,陕西西安710003
出 处:《山东大学耳鼻喉眼学报》2022年第4期55-59,共5页Journal of Otolaryngology and Ophthalmology of Shandong University
摘 要:目的学习和掌握新生儿咽旁间隙卡梅现象(KMP)的临床特点、诊断及治疗方案的选择。方法回顾总结1例新生儿咽旁间隙KMP的诊疗过程,并复习相关文献。结果患儿先期治疗采用泼尼松和普萘洛尔联合口服效果不佳,后改用博来霉素、地塞米松混合液瘤体内灌注,分二期完成治疗,间隔1个月,瘤体消失,实验室检查正常。随访2年,患儿恢复良好,无不良反应出现及后遗症发生。结论KMP是一种对婴幼儿危害较大的罕见疾病,发生于咽旁间隙尤为少见,目前尚无统一治疗方案,需个体化制定治疗措施。病例提示对于难以手术切除和全身用药治疗效果不佳的患儿,博来霉素、地塞米松局部注射是安全有效的治疗手段。Objective We aimed to evaluate-the clinical characteristics,the diagnosis,and treatment of Kasabach-Merritt phenomenon(KMP)in newborns.Methods We retrospectively analyzed a case of new born with KMP in parapharyngeal space,along with a review of the related literature.Results In this case,oral administration of Prednisone and Propranolol was ineffective.As such,a combined solution of bleomycin and dexamethasone was injected into the tumor,and the treatment was completed in two stages,with an interval of one month.The tumor eventually resolved,and laboratory examinations were found to be normal.The patient was followed up for 2 years who showed good recovery without adverse reactions or sequelae.Conclusion KMP is a rare but greatharmful disease among in fants,especially rare in the parapharyngeal space.As there is no unified treatment at presen,there is a need for effective individualized management.This particular case shows that local injection of bleomycin and dexame thasone may be a safe and effective treatment in neonates with difficult surgical resection who are resistant to systemic medication.
分 类 号:R766.9[医药卫生—耳鼻咽喉科]
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