喉癌干细胞:克服多药耐药性的潜在治疗靶点  

Laryngeal cancer stem cells:potential therapeutic targets for overcoming multidrug resistance

作　　者：王媚(综述) 李志海(审校)[2] WANG Mei;LI Zhihai(The First Clinical Medical College of WenZhou Medical University,Wenzhou 325025,Zhejiang,China;Department of Otolaryngology,Taizhou Municipal Hospital,Taizhou 317700,Zhejiang,China)

机构地区：[1]温州医科大学第一临床医学院,浙江温州325025 [2]台州市立医院耳鼻喉科,浙江台州317700

出　　处：《山东大学耳鼻喉眼学报》2022年第4期120-128,共9页Journal of Otolaryngology and Ophthalmology of Shandong University

摘　　要：喉癌是头颈部最常见的恶性肿瘤之一,尽管喉癌检测和治疗的进步增加了早期治愈的可能性,但大多数患者最终因耐药和复发而死亡,因此治疗耐药性和转移是当今喉癌治疗的主要挑战。随着研究的深入,肿瘤干细胞的存在已被证明与肿瘤发生和治疗抗性密切相关。喉癌的早期诊断和治疗有赖于肿瘤干细胞标志物的发现和鉴定,这对喉癌的靶向治疗有着深远的意义。回顾了目前国内外对喉癌干细胞的研究,从肿瘤干细胞起源,喉癌干细胞可能的耐药机制、并对维持喉癌干性的表面标志物与喉癌靶向治疗的相关进展进行综述,旨在为喉癌的临床治疗提供新的方向及作用靶点。Laryngeal cancer is a common malignancy in the head and neck.Although,detection and treatment of laryngeal cancer advances have increased the possibility of early diagnosis and treatment,most patients eventually die due to drug resistance and recurrence.Therefore,drug resistance and metastasis are the major challenges in laryngeal cancer treatment.As research progresses,the existence of tumor stem cells was proven to be closely associated with tumorigenesis and treatment resistance.The early diagnosis and treatment of laryngeal cancer depend on the detection and identification of the tumor stem cell markers,which have far-reaching implications for targeted therapy of laryngeal cancer.This study reviewed the current research on laryngeal cancer stem cells at home and abroad,its origin,and possible drug resistance mechanism of laryngeal cancer stem cells.Additionally,this study reviewed the surface markers that maintain the stemness of laryngeal cancer and progress of targeted therapy for laryngeal cancer,which aims to provide new directions and targets for clinical treatment of laryngeal cancer.

关 键 词：喉癌 肿瘤干细胞标记物 多药耐药 靶向治疗 

分 类 号：R767[医药卫生—耳鼻咽喉科]