白细胞介素-22在哮喘气道重塑中的作用研究进展  

Role of interleukin-22 in airway remodeling of asthma:A review of recent studies

作　　者：何贵强 郎艳竹 赵顺顺 王小静 欧阳瑶 HE Guiqiang;LANG Yanzhu;ZHAO Shunshun;WANG Xiaojing;OUYANG Yao(Department of PCCM and Critical Care Medicine Respi-ratory,Affiliated Hospital of Zunyi Medical University,Zunyi 563000,China)

机构地区：[1]遵义医科大学附属医院呼吸与危重症医学科,贵州遵义563000

出　　处：《实用医学杂志》2022年第19期2491-2494,2500,共5页The Journal of Practical Medicine

基　　金：国家自然科学基金项目(编号:82060005);贵州省科技计划项目(编号:黔科合支撑[2020]4Y141号)。

摘　　要：白细胞介素-22(interleukin-22,IL-22),由CD4+T细胞亚群产生,具有宿主防御和保护上皮的功能。IL-22是一种促炎细胞因子,在哮喘气道炎症中发挥重要作用。同时,IL-22可加剧上皮下纤维化、促进上皮间质转化(EMT)、黏液分泌增加、气道平滑肌增生和肥大,从而加重哮喘的气道重塑。IL-22作为一种促炎和促纤维因子,在哮喘的气道重塑中的具体机制目前尚不明确,本文就IL-22在哮喘气道重塑中的作用展开综述。Interleukin-22(IL-22),produced by the CD4+T cell subpopulation,plays a role in host defense and epithelial protection.As a pro-inflammatory cytokine,IL-22 plays an important role in airway inflammation in asthma.Meanwhile,IL-22 can aggravate subepithelial fibrosis,promote EMT,increase mucus secretion,and hyperplasia and hypertrophy of airway smooth muscle,thus aggravating airway remodeling in asthma.As a pro-inflammatory and pro-fibrogenic factor,the specific mechanism of IL-22 in airway remodeling in asthma is still unclear.This article reviews the role of IL-22 in airway remodeling in asthma.

关 键 词：白细胞介素-22 哮喘 气道重塑 

分 类 号：R562.1[医药卫生—呼吸系统]