纳米酶:新一代人工酶  

Nanozymes:next-generation artificial enzymes

作　　者：高利增[1,2] 陈雷 张若飞 阎锡蕴 Lizeng Gao;Lei Chen;Ruofei Zhang;Xiyun Yan(CAS Engineering Laboratory for Nanozyme,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China;Nanozyme Medical Center,School of Basic Medical Sciences,Zhengzhou University,Zhengzhou 450001,China;Shenzhen Institute of Synthetic Biology,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China)

机构地区：[1]中国科学院纳米酶工程实验室,中国科学院生物物理研究所,北京100101 [2]郑州大学医学院纳米酶医学研究中心,郑州450001 [3]深圳合成生物学创新研究院,中国科学院深圳先进技术研究院,深圳518055

出　　处：《中国科学：化学》2022年第9期1649-1663,共15页SCIENTIA SINICA Chimica

基　　金：国家重点研发计划(编号:2019YFA0709200);国家自然科学基金(编号:22121003,81930050)资助项目。

摘　　要：纳米酶是中国科学家提出的新概念,已经被纳入教科书和百科全书.汪尔康院士团队最先将纳米酶用于分析检测,并在国际权威期刊发表长篇综述“纳米酶:新一代人工酶”.该文不仅提升了纳米酶的国际影响力,而且推动了纳米酶的应用研究,使纳米酶新品种、新技术和新产品不断涌现,形成了纳米酶新型交叉学科.在此基础上,本文概述了纳米酶的定义、分类和催化机制,介绍了其应用研究的最新进展,并对其未来的研究方向和发展趋势进行了展望.Nanozymes are a new concept created by Chinese scientists and have been recorded in textbooks and encyclopedia.Prof.Erkang Wang pioneered to utilize nanozymes for analytical detection and then published a review entitled“Nanomaterials with enzyme-like characteristics(nanozymes):next-generation artificial enzymes”.These contributions not only expand the impact of nanozymes,but also facilitate the translational applications of nanozymes,leading to an interdisciplinary hot spot with emerging new materials,technologies and products of nanozymes.In this paper,the definition,classification and catalytic mechanism of nanozymes are introduced,and the recent progress of their application is summarized.The future research directions and development trends are also proposed.

关 键 词：纳米酶 天然酶 理性设计 催化机理 转化应用 

分 类 号：TQ426.97[化学工程] TB383.1[一般工业技术—材料科学与工程]