细胞生物信息学及技术  

Cell bioinformatics and technology

作　　者：顾宁[1,2] 王方旭 李艳 汤天宇 曹晨 沈艳 Ning Gu;Fangxu Wang;Yan Li;Tianyu Tang;Chen Cao;Yan Shen(State Key Laboratory of Bioelectronics,Jiangsu Key Laboratory for Biomaterials and Devices,School of Biological Science and Medical Engineering,Southeast University,Nanjing 210096,China;School of Biomedical Engineering and Informatics,Nanjing Medical University,Nanjing 211166,China;School of Medicine,Jiangsu Key Laboratory of Molecular Imaging and Function Imaging,Southeast University,Nanjing 210096,China)

机构地区：[1]东南大学生物科学与医学工程学院,生物电子学国家重点实验室,江苏省生物材料与器件重点实验室,南京210096 [2]南京医科大学生物医学工程与信息学院,南京211166 [3]东南大学医学院,江苏省分子影像与功能影像重点实验室,南京210096

出　　处：《中国科学：化学》2022年第9期1673-1684,共12页SCIENTIA SINICA Chimica

基　　金：国家自然科学基金(编号:61821002,51832001,92163213)资助项目。

摘　　要：细胞是生命体基本组成单位,其性状与活动过程直接关乎生命体生理与病理.近年来,有关(单)细胞的研究突飞猛进.细胞命运、操控及其生物医学应用首先必须有细胞信息获取与分析作为支撑,但由于技术原理与方法等方面还存在许多难以克服的限制,相关研究亟待突破.本文简述了细胞生物信息学的由来与分类,梳理了细胞生物信息获取与分析研究的主要进展,并对未来的发展趋势与挑战进行了讨论.Cell is the basic unit of life.The characteristics and activity process of cells are directly related to the physiology and pathology of life.In recent years,the research on(single)cells has made rapid progress.Understanding cell fate,manipulation and biomedical applications must firstly be supported by cell information acquisition and analysis.Due to the insurmountable limitations in technical principles and methods,relevant research needs to be broken through.This article introduces origin and classification of cell bioinformatics,summarizes the main progress in cell bioinformatics acquisition and analysis,and discusses the future development trend and challenges.

关 键 词：细胞生物信息学 单细胞分析 图像处理 谱学分析 细胞温度 

分 类 号：Q811.4[生物学—生物工程]