静电纺丝技术在纤维环组织工程中的研究进展  

Research progress of electrospinning used in annulus fibrosus tissue engineering

作　　者：吴锐邦 黄勇[1] 黄雷震 王竞成 王珏翰 丰干钧[1] 刘立岷[1] 宋跃明[1] WU Ruibang;HUANG Yong;HUANG Leizhen;WANG Jingcheng;WANG Juehan;FENG Ganjun;LIU Limin;SONG Yueming(Department of Orthopedic Surgery,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,P.R.China)

机构地区：[1]四川大学华西医院骨科,成都610041

出　　处：《华西医学》2022年第10期1569-1575,共7页West China Medical Journal

基　　金：国家自然科学基金(82172495,81871772,82072434);四川省科学技术厅科技计划项目(2020YFS0143,2021YFS0218);四川省科学技术厅重大技术专项项目(2022ZDZX0029);四川大学华西医院学科发展1·3·5工程临床研究孵化项目(2021HXFH003)。

摘　　要：椎间盘退变疾病是一种常见的慢性疾病,也是目前骨科医师面临的挑战。手术是治疗椎间盘退变疾病的主要方法,但在临床实践中仍存在固有的局限性,而组织工程为是目前最有前途的椎间盘修复及再生提供了潜在的治疗手段方法。其中静电纺丝技术是一种制备纳米级纤维的方法,不同材料和参数的静电纺丝材料具有不同的力学性能、孔隙率和取向,可以模拟天然椎间盘的结构特征和力学性能。因此,静电纺丝材料可用于椎间盘的替代和再生。该文综述了椎间盘组织工程进展以及用于制备椎间盘支架常用的静电纺丝纳米材料,对目前和未来可能提高静电纺丝纤维性能的方法进行了介绍。Degenerative disc disease is a prevalent chronic disease that orthopaedic surgeons currently face as a difficulty. Tissue engineering represents the most promising possible therapeutic strategy for disc repair and regeneration.Surgery is the primary treatment for degenerative disc disease, but there are still inherent limits in practical practice.Electrospinning technique is a method for manufacturing nanoscale fibers with varied mechanical properties, porosity,and orientation, which can imitate the structural qualities and mechanical properties of natural intervertebral discs.Therefore, electrospinning materials can be utilized for disc regeneration and replacement. This article reviews recent advancements in disc tissue engineering and electrostatically spun nanomaterials typically utilized for the fabrication of disc scaffolds, as well as present and future techniques that may enhance the performance of electrostatically spun fibers.

关 键 词：组织工程 纤维环 静电纺丝 椎间盘退行性变 支架 再生 

分 类 号：R318.08[医药卫生—生物医学工程]