被误诊为神经纤维瘤病的多发性皮肤平滑肌瘤  

A case of multiple cutaneous leiomyoma misdiagnosed as neurofibromatosis

作　　者：葛祎 陈明亮[1] 粟娟[1] GE Yi;CHEN Ming-liang;SU Juan(Department of Dermatology,Xiangya Hospital of Central South University,Changsha 410008,China)

机构地区：[1]中南大学湘雅医院皮肤科,湖南长沙410008

出　　处：《临床皮肤科杂志》2022年第11期660-662,共3页Journal of Clinical Dermatology

基　　金：国家自然科学基金(81974478)资助项目。

摘　　要：报告1例多发性皮肤平滑肌瘤。患者男,40岁,躯干、四肢丘疹和结节10年,加重5年,曾被当地医院误诊为神经纤维瘤病。左肩部结节组织病理检查:真皮内梭形细胞增生,呈束状或团块状排列,梭形细胞核长而钝圆,无明显异形性.细胞质嗜酸性,部分细胞质内见空泡,细胞间有胶原束。免疫组化:平滑肌肌动蛋白(SMA)及平滑肌结蛋白(desmin)均阳性,增殖核抗原(Ki-67)1%阳性,血小板内皮细胞黏附分子(CD31),CD34、神经丝蛋白(NFP)及S-100蛋白均阴性。诊断:多发性皮肤平滑肌瘤。A case of multiple cutaneous leiomyoma is reported.A 40-year-old man presented with papules and nodules on the trunk and extremities for 10 years,which were aggravated for 5 years,and had been misdiagnosed as neurofibromatosis by the local hospital.Histopathological examination of nodules on the left shoulder revealed dermal proliferation of spindle cells in bundles or clumps,with long and blunt spindle nuclei but without significant atypia.Eosinophilic cytoplasm,vacuoles in cyto plasm,and collagen bundles between cells were also found.Immunohistochemistry showed positivity for SMA and smooth muscle desmin,Ki-67 was 1%positive,and negative results for CD31,CD34,NFP,and S-100.The diagnosis of multiple cutaneous leiomyomawas made.

关 键 词：皮肤平滑肌瘤 多发性 

分 类 号：R739.5[医药卫生—肿瘤]