阻塞性睡眠呼吸暂停低通气综合征伴发高血压患者血清儿茶酚抑素、氧化应激指标变化及其与血压的相关性  

The change of catecholamines and oxidative stress index in obstructive sleep apnea hypopnea syndrome with hypertension patients and the correlation with blood pressure

作　　者：周金玲[1] 贺红霞[1] 陈会林 龚清永[1] 金明[1] Zhou Jinling;He Hongxia;Chen Huilin;Gong Qingyong;Jin Ming(Department of Respiratory and Critical Care Medicine,Jingmen No.1 People′s Hospital,Jingmen 448000,China)

机构地区：[1]荆门市第一人民医院呼吸与危重症医学科,荆门448000

出　　处：《中国医师进修杂志》2022年第10期930-933,共4页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)伴发高血压患者血清儿茶酚抑素(CST)、氧化应激指标变化及与血压的相关性。方法选取荆门市第一人民医院2018年2月至2020年8月收治的100例OSAHS患者,根据患者是否合并高血压分为OSAHS组(54例)与OSAHS合并高血压组(46例),比较两组临床资料及血清CST、氧化应激指标的差异。分析血压与血清CST、氧化应激指标的相关性。结果OSAHS合并高血压组血清髓过氧化物酶(MPO)水平高于OSAHS组[(41.67±3.02)U/L比(39.11±2.65)U/L],血清过氧化氢酶(CAT)、CST水平低于OSAHS组[(11.47±2.54)kU/L比(15.88±2.31)kU/L、(23.63±4.38)ng/L比(28.61±5.42)ng/L],差异有统计学意义(P<0.05)。两组呼吸紊乱指数、最低血氧饱和度、三酰甘油、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、肾上腺素、去甲肾上腺素水平比较差异均无统计学意义(P>0.05)。Spearman相关分析结果表明,收缩压、舒张压与OSAHS患者血清MPO水平呈正相关(P<0.05),与血清CAT、CST水平呈负相关(P<0.05)。结论OSAHS伴高血压患者血清CST、CAT水平降低,MPO水平升高,氧化应激可能与OSAHS伴发高血压有关。Objective To investigate the changes of serum catecholamines(CST)and oxidative stress index in patients with obstructive sleep apnea hypopnea syndrome(OSAHS)with hypertension and the correlation with blood pressure.Methods Total of 100 OSAHS patients admitted to Jingmen No.1 People′s Hospital from February 2018 to August 2020 were selected.According to whether patients combined with hypertension,they were divided into OSAHS group(54 cases)and OSAHS combined with hypertension group(46 cases).The changes of serum CST and oxidative stress index in the two groups were compared and analyzed the correlation of blood pressure and CST and oxidative stress index.Results The level of myeloperoxidase(MPO)in the OSAHS combined with hypertension group was higher than that in the OSAHS group:(41.67±3.02)U/L vs.(39.11±2.65)U/L;the levels of catalase(CAT)and CST in the OSAHS combined with hypertension group were higher than those in the OSAHS group:(11.47±2.54)kU/L vs.(15.88±2.31)kU/L,(23.63±4.38)ng/L vs.(28.61±5.42)ng/L,there were statistically differences(P<0.05).The levels of respiratory disturbance index,lowest oxygen saturation,triacylglycerol,total cholesterol,low density lipoprotein cholesterin,high density lipoproteincholesterol,epinephrine,noradrenaline in the two groups had no significant differences(P>0.05).Spearman correlation analysis showed that the systolic pressure and diastolic pressure had positive correlation with MPO(P<0.05),and had negative correlation with CAT and CST(P<0.05).Conclusions The serum CST and CAT are down-regulated in patients with OSAHS with hypertension,and serum MPO is up-regulated.Oxidative stress may be related to OSAHS with hypertension.

关 键 词：睡眠呼吸暂停 阻塞性 高血压 肺性 儿茶酚胺类 氧化性应激 相关 

分 类 号：R766[医药卫生—耳鼻咽喉科] R544.1[医药卫生—临床医学]