多巴胺超敏性精神病的发生机制和治疗的研究现状  

Current status of research on pharmacological mechanisms and treatment of dopamine hypersensitivity psychosis

作　　者：吕钦谕[1,2] 汪崇泽 肖旭东 吴希 王苹 徐兰 易正辉 Lyu Qinyu;Wang Chongze;Xiao Xudong;Wu Xi;Wang Ping;Xu Lan;Yi Zhenghui(Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200030,China;Department of Psychiatry,Huashan Hospital,Fudan University,Shanghai 200040,China)

机构地区：[1]上海交通大学医学院附属精神卫生中心,200030 [2]复旦大学附属华山医院,上海200040

出　　处：《神经疾病与精神卫生》2022年第10期725-729,共5页Journal of Neuroscience and Mental Health

基　　金：上海交通大学“交大之星”计划医工交叉研究基金项目(YG2019QNB07)。

摘　　要：多巴胺超敏性精神病(DSP)是指长期高剂量服用抗精神病药物后出现反弹性精神病、药物耐受性增加和迟发性运动障碍(TD)。目前,DSP的发生机制不明确,缺乏有效的治疗方法。然而,DSP在精神分裂症患者中的流行率较高,尤其在治疗抵抗的精神分裂症患者中。近年来,有许多临床研究关注到DSP,掌握其发生机制并进行有效治疗可以缩短患者疾病病程,改善患者整体预后。因此,现对DSP的发生机制和治疗现状进行综述。Dopamine supersensitivity psychosis(DSP)refers to the development of rebound psychosis,increased drug tolerance,and tardive dyskinesia(TD)after chronic and high dose of antipsychotic drugs in patients with schizophrenia.The mechanism of DSP is currently unclear,and there is a lack of effective treatment.However,the prevalence of DSP remains high in patients with schizophrenia,especially in treatmentresistant schizophrenic patients.Many clinical studies have focused on DSP in recent years.Mastering its mechanisms of occurrence and effective treatment can shorten the disease course and improve the overall prognosis of patients.Therefore,this paper presents a review of the pharmacological mechanisms and treatment of DSP.

关 键 词：超敏性精神病 多巴胺D_(2)受体超敏性 抗精神病药物 迟发性运动障碍 精神分裂症 综述 

分 类 号：R749[医药卫生—神经病学与精神病学]