基于关联规则和聚类分析探讨《医宗必读》中治疗痹证的用药规律  

Discusses the law of drug in treating arthralgia syndrome in Yizong Bidu based on association rules and cluster analysis

作　　者：潘晓幢 周大勇[2] PAN Xiaozhuang

机构地区：[1]安徽中医药大学,安徽合肥230038 [2]安徽中医药大学第一附属医院,安徽合肥230031

出　　处：《中医临床研究》2022年第28期110-113,共4页Clinical Journal Of Chinese Medicine

摘　　要：目的:分析李中梓《医宗必读》中关于痹证的用药规律及科学内涵,探寻李中梓在诊疗痹证方面的用药特色。方法:了解《医宗必读》中关于痹证的病因病机,利用其中所记载方剂建立数据库,并运用关联规则、聚类分析等方法,分析使用频率较高的中药的性味归经、配伍组合,以探究李中梓对于痹证的治则治法及用药规律。结果:(1)《医宗必读》中有关治疗痹证的方剂共16首,涉及中药68味,所用中药涉及寒、热、温、凉、平性,主要集中于温、热、平性。(2)所用中药涉及酸、苦、甘、辛、咸、淡、涩味,以辛、苦、甘味最为频繁。(3)归经以肝、脾、肺、心、胃、肾经为主。(4)处方中药主要集中于祛风除湿、健脾化湿、活血化瘀、祛风通络4类药,其中以祛风除湿类药为主。(5)基于关联规则获得置信度与关联度较高的分组:甘草-白芍;甘草-茯苓;当归-地龙;当归-茯苓。(6)聚类分析得出:海桐皮、天麻;防风、羌活;白僵蚕、地龙、木香;陈皮、麻黄4组。结论:李中梓治痹,寒热并用,既循于法,又超于外,为临床上痹证的治疗提供了很好的诊疗思路和用药指导。Objective:To analyze the medication rules and scientific connotations of TCM for Bi syndrome(痹证)in Yizong Bidu(《医宗必读》),a classic work of TCM master LI Zhongzi,and explore LI Zhongzi’s medication characteristics in the diagnosis and treatment of Bi syndrome.Methods:The etiology and pathogenesis of Bi syndrome described in Yizong Bidu were understood.A database of the prescriptions recorded in the work was established.The association rules,cluster analysis and other methods were used to analyze the medicinal properties,medicinal tastes,meridian tropism,and compatibility combination of high frequency medicines,in order to explore LI Zhongzi’s treatment principles and medication rules for the treatment of Bi syndrome.Results:(1)There were 16 prescriptions on Bi syndrome in Yizong Bidu,involving 68 TCM medicines.The medicinal properties involved cold,heat,warm,cool and moderate,mainly focusing on warm,heat and moderate.(2)The medicinal tastes involved sour,bitter,sweet,spicy,salty,light and astringent,and the spicy,bitter and sweet tastes were the most frequent used.(3)Meridian tropisms were mainly liver,spleen,lung,heart,stomach and kidney meridians.(4)The medicines in the prescriptions could be mainly classified into four categories:dispelling wind and dampness,invigorating spleen to remove dampness,promoting blood circulation and removing blood stasis,and dispelling wind and dredging collaterals,among which dispelling wind and dampness medicines were the main medicine used.(5)The groups with higher confidence and correlation based on association rule were Gancao(Licorice)-Baishao(White peony),Gancao-Fuling(Poria cocos),Danggui(Chinese angelica)-Dilong(Earthworm),Danggui-Fuling.(6)The cluster analysis obtained four groups of correlation results:Haitongpi(Pittosporum bark)-Tianma(Gastrodia elata),Fangfeng(Saposhnikovia divaricata)-Qianghuo(Notopterygium incisum),Baijiangcan(White silkworm)-Dilong-Muxiang(Radix Aucklandiae),and Chenpi(Dried tangerine)-Mahuang(Ephedra).Conclusion:TCM master LI Zhong

关 键 词：《医宗必读》 痹证 关联分析 聚类分析 数据挖掘 

分 类 号：R255.6[医药卫生—中医内科学]