2012-2020年某三甲医院链球菌属的分布及耐药性分析  

Distribution and drug resistance analysis of Streptococcus in a third class A hospital from 2012 to 2020

作　　者：邓懋清 刘辉 肖婷 郑小凤 陈丽萍 DENG Maoqing;LIU Hui;XIAO Ting;ZHENG Xiaofeng;CHEN Liping(Department of Clinical Laboratory,Longyan First Affiliated Hospital of Fujian Medical University,Longyan,Fujian 364000,China)

机构地区：[1]福建医科大学附属龙岩第一医院检验科,福建龙岩364000

出　　处：《检验医学与临床》2022年第21期2929-2932,2936,共5页Laboratory Medicine and Clinic

基　　金：福建省自然科学基金项目(2019J01615)。

摘　　要：目的分析链球菌属的分布及对常用抗菌药物的耐药情况。方法收集2012-2020年该院临床标本分离的菌株,采用Phoenix 100全自动细菌分析仪进行菌株鉴定和药敏试验。结果9年间共检出链球菌2365株,前7位分离菌分别是肺炎链球菌(SPN)、无乳链球菌(SGC)、咽峡炎链球菌(SAN)、星座链球菌(SCT)、缓症链球菌(SMT)、少酸链球菌(SAD)和化脓性链球菌(SPY)。标本主要来自痰、伤口脓液、生殖道分泌物和血等。835株SPN分离自非脑脊液标本,其中成人799株,儿童36株,成人分离株对青霉素的敏感率为57.6%,高于儿童的42.9%。SGC和SPY对β-内酰胺类药物敏感度高。SMT、SAD的耐药率要高于SAN和SCT。所有链球菌对红霉素、克林霉素和四环素的耐药率较高,未发现对利奈唑胺和万古霉素耐药。结论SPN和SGC在该院的分离率较高,SPN对青霉素的耐药率呈曲折上升趋势,应加强对链球菌的分布及耐药情况的监测。Objective To analyze the distribution of Streptococcus and its resistance to commonly used antibiotics.Methods Strains isolated from clinical specimens of the hospital from 2012 to 2020 were identified and drug sensitivity test was performed by Phoenix 100.Results A total of 2365 strains of Streptococcus were detected during the 9 years.Results The top seven isolated were Streptococcus pneumoniae(SPN),Streptococcus agalactiae(SGC),Streptococcus anginosus(SAN),Streptococcus constellatus(SCT),Streptococcus mitis(SMT),Streptococcus acidominimus(SAD)and Streptococcus pyogenes coccus(SPY).The samples were mainly from sputum,wound pus,vaginal secretions and blood.835 SPN were isolated from non-cerebrospinal fluid samples,including 799 from adults and 36 from children.The sensitivity rate of adult isolates to penicillin was 57.6%,which was higher than that of children(42.9%).β-lactams were highly sensitive to Streptococcus agalactiae and Streptococcus pyogenes coccus.The drug resistance rate of Streptococcus mitis and Streptococcus acidominimus was higher than that of Streptococcus anginosus and Streptococcus constellatus.All Streptococcus had high resistance rates to erythromycin,clindamycin and cyclomycin,but no resistance to linezolid and vancomycin was found.Conclusion The isolation rates of Streptococcus pneumoniae and Streptococcus agalactiae are the highest in this hospital.The resistance rate of Streptococcus pneumoniae to penicillin shows a tortuous upward trend,and the monitoring of the distribution and resistance of Streptococcus should be strengthened.

关 键 词：链球菌 耐药性 耐青霉素肺炎链球菌 

分 类 号：R978.1[医药卫生—药品]