男性患者泌尿生殖道病原体感染情况分析  

Analysis of urogenital tract pathogen infection in male patients

作　　者：陈海明[1] 逯晓辉[1] 杨园园 刘伦 王前明[1] CHEN Haiming;LU Xiaohui;YANG Yuanyuan;LIU Lun;WANG Qianming(Department of Clinical Laboratory,the First Affiliated Hospital of Xiamen University/Xiamen Key Laboratory of Genetic Testing,Xiamen,Fujian 361001,China)

机构地区：[1]厦门大学附属第一医院检验科/厦门市基因检测重点实验室,福建厦门361001

出　　处：《检验医学与临床》2022年第21期2937-2940,共4页Laboratory Medicine and Clinic

基　　金：福建省自然科学基金项目(2019J01568)。

摘　　要：目的分析厦门大学附属第一医院男性就诊者4种泌尿生殖道病原体检出情况及感染特征,为该地区相关疾病的临床诊疗工作提供科学依据。方法选取2019年1-12月厦门大学附属第一医院门诊男性患者的沙眼衣原体(CT)、淋病奈瑟菌(NG)、生殖支原体(MG)、解脲脲原体(UU)实时荧光核酸恒温扩增(SAT)检测结果,结合其临床诊断资料进行统计分析。结果2735例男性门诊患者CT、NG、MG、UU总阳性率分别为6.1%、3.2%、3.2%、27.7%,UU阳性率显著高于其他3种病原体,差异有统计学意义(P<0.05)。不同感染类型分析结果显示:单独感染类型阳性率由高到低分别为单独UU感染(24.6%)、单独CT感染(3.7%)、单独NG(2.3%)、单独MG感染(2.1%);混合感染类型以CT+UU混合感染和MG+UU混合感染为主,阳性率分别为1.7%和1.1%。按年龄段分层分析显示感染人群主要集中在20~<30岁和30~<40岁,NG、MG阳性率最高的年龄段均为<20岁,但不同年龄段男性患者在各病原体阳性率中的比较差异无统计学意义(P>0.05)。在临床诊断明确的男性就诊者中:CT阳性率最高的为附睾炎(28.6%);NG和MG阳性率则以泌尿道感染最高,分别为23.3%和9.0%,UU阳性率较高的前3位分别为精液异常、男性不育症和性功能障碍,阳性率分别为34.8%、34.4%、33.9%。结论该院男性患者CT、NG、MG、UU 4种泌尿生殖道病原体阳性率较高,且存在一定的合并感染,临床诊疗应注意联合检测,防止漏检。Objective To analyze the detection rate and infection characteristics of 4 kinds of urogenital tract pathogens in male patients in the First Affiliated Hospital of Xiamen University,and to provide scientific basis for clinical diagnosis and treatment of related diseases in this area.Methods The results of real-time fluorescent nucleic acid constant temperature amplification(SAT)detection of four pathogens[Chlamydia trachomatis(CT),Neisseria gonorrhoeae(NG),Mycoplasma genitalium(MG),Ureaplasma urealyticum(UU)]in male outpatients of the First Affiliated Hospital of Xiamen University from January to December 2019 were selected for statistical analysis combined with their clinical diagnostic data.Results The positive rates of CT,NG,MG and UU in 2735 male outpatients were 6.1%,3.2%,3.2%and 27.7%,respectively.The positive rates of UU were significantly higher than those of other three pathogens,the difference was statistically significant(P<0.05).Analysis results of different infection types showed that the positive rate of single infection type from high to low was UU infection(24.6%),CT infection(3.7%),NG infection(2.3%),MG infection(2.1%).CT+UU mixed infection and MG+UU mixed infection were the main types of mixed infection,with positive rates of 1.7%and 1.1%,respectively.Stratified analysis by age showed that the infected population mainly concentrated in 20-<30 years old and 30-<40 years old,the highest positive rates of NG and MG were less than 20 years old,but there was no significant difference in the positive rate of each pathogen in male patients of different ages(P>0.05).In male patients with definite clinical diagnosis,the CT positive rate was the highest in epididymitis(28.6%),NG and MG positive rates were the highest in urinary tract infection(23.3%and 9.0%,respectively).The top three positive rates of UU were 34.8%,34.4%and 33.9%in patients with semen abnormality,male infertility and sexual dysfunction,respectively.Conclusion The positive rate of CT,NG,MG and UU pathogens in male patients in this hospita

关 键 词：沙眼衣原体 淋病奈瑟菌 生殖支原体 解脲脲原体 感染 

分 类 号：R691.3[医药卫生—泌尿科学]