固本扶正汤对宫颈癌化疗患者KISS-1蛋白及Th1/Th2平衡影响  

Effects of Guben Fuzheng Decoction on KISS-1 Protein and Th1/Th2 Balance in Patients with Cervical Cancer Chemotherapy

作　　者：宋洪杰 SONG Hongjie(Department of Oncology,Beidahuang Group General Hospital,Harbin,Heilongjiang Province,150088 China)

机构地区：[1]北大荒集团总医院肿瘤二科,黑龙江哈尔滨150088

出　　处：《中外医疗》2022年第17期9-12,25,共5页China & Foreign Medical Treatment

摘　　要：目的探讨固本扶正汤对宫颈癌化疗患者转移抑制基因(KISS-1)蛋白及Th1/Th2平衡影响。方法便利选取2019年8月—2021年8月北大荒集团总医院收治的宫颈癌患者92例,随机分为对照组(n=46)和观察组(n=46)。对照组行常规化疗,观察组在化疗同时给予固本扶正汤治疗。对比两组治疗疗效、KISS-1蛋白及血清Th1/Th2相关因子水平。结果观察组治疗有效率(82.61%)高于对照组(63.04%),差异有统计学意义(χ^(2)=4.449,P<0.05)。治疗后,观察组KISS-1蛋白阳性表达率、血清IFN-γ、IL-2水平高于对照组,IL-4低于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率均低于对照组,差异有统计学意义(P<0.05)。结论固本扶正汤对宫颈癌化疗患者的治疗疗效确切,可促进KISS-1蛋白表达增加,改善细胞免疫水平,并可减少不良反应发生,值得临床进一步推广。Objective To investigate the effect of Guben Fuzheng decoction on the protein of metastasis suppressor gene(KISS-1)and the balance of Th1/Th2 in patients with cervical cancer undergoing chemotherapy.Methods A total of 92 cervical cancer patients admitted to Beidahuang Group General Hospital from August 2019 to August 2021 were conveniently selected and randomly divided into control group(n=46)and observation group(n=46).The control group was given conventional chemotherapy,while the observation group was given Guben Fuzheng Decoction at the same time of chemotherapy.The therapeutic efficacy,KISS-1 protein and serum Th1/Th2-related factor levels were compared between the two groups.Results The effective rate of treatment in the observation group(82.61%)was higher than that in the control group(63.04%),the difference was statistically significant(χ^(2)=4.449,P<0.05).After treatment,the positive expression rate of KISS-1 protein,serum IFN-γand IL-2 levels in the observation group were higher than those in the control group,and IL-4 was lower than that in the control group,the difference was statistically significant(P<0.05).The incidences of adverse reactions such as leukopenia in the observation group were lower than those in the control group,the difference was statistically significant(P<0.05).Conclusion Guben Fuzheng Decoction has definite curative effect on patients with cervical cancer chemotherapy,can promote the increase of KISS-1 protein expression,improve the level of cellular immunity,and reduce the occurrence of adverse reactions,which is worthy of further clinical promotion.

关 键 词：宫颈癌 固本扶正汤 化疗 KISS-1蛋白 TH1/TH2 

分 类 号：R4[医药卫生—临床医学]