从腔内影像学进展探讨冠状动脉易损斑块的临床意义  

The Vulnerable Plaque:Intracoronary Imaging and Clinical Value

作　　者：刘春伟[1] 胡越成[1] 张敬霞[1] 王林[1] 丛洪良[1] LIU Chunwei;HU Yuecheng;ZHANG Jingxia;WANG Lin;CONG Hongliang(Department of Cardiology,Tianjin Chest Hospital,Tianjin 300222,China)

机构地区：[1]天津市胸科医院心内科,天津300222

出　　处：《心血管病学进展》2022年第10期877-882,共6页Advances in Cardiovascular Diseases

基　　金：天津市卫生健康委员会面上项目(MS20016)。

摘　　要：近年来腔内影像学技术突飞猛进,为冠状动脉粥样硬化斑块的病理生理演变提供了丰富的信息。既往研究集中于早期检测识别冠状动脉易损斑块,但这些易损斑块对临床事件的阳性预测值很低。现总结近年来在冠状动脉易损斑块领域内的大量临床相关研究,阐述易损斑块对临床事件的预测价值及其在冠状动脉粥样硬化疾病自然进程中的意义。Intracoronary imaging has been developed greatly in recent years,it provided abundant information about the pathophysiology and evolution of coronary atherosclerotic plaque.Previous studies focused on the early identification of vulnerable atherosclerotic plaque,yet the positive predictive value of imaging precursors of the vulnerable plaque remains too low for clinical relevance.This review summarizes the numerous clinical studies on the vulnerable plaque in recent years,and discusses its predictive value of adverse events and its role in the natural history of coronary atherosclerotic disease.

关 键 词：易损斑块 薄纤维帽粥样硬化斑块 血管内超声 近红外线成像 光学相干断层成像 内皮剪切应力 斑块侵蚀 

分 类 号：R541.4[医药卫生—心血管疾病]