非编码RNA在代谢性心血管疾病中的研究及治疗现状  

Research and Treatment Status of Non-Coding RNA in Metabolic Cardiovascular Disease

作　　者：林力 陈敏[2] 梁明露 宁璐璐 王紫 黄恺[1,2] LIN Li;CHEN Min;LIANG Minglu;NING Lulu;WANG Zi;HUANG Kai(Department of Cardiology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,Hubei,China;Clinic Center of Human Gene Research,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,Hubei,China;Cardiovascular Center,Liyuan Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430062,Hubei,China;Hubei Prevention and Therapeutic Center for Cardiovascular Diseases,Wuhan 430062,Hubei,China)

机构地区：[1]华中科技大学同济医学院附属协和医院心血管内科,湖北武汉430022 [2]华中科技大学同济医学院附属协和医院人类基因组临床研究中心,湖北武汉430022 [3]华中科技大学同济医学院梨园心血管临床医学中心,湖北武汉430062 [4]湖北省心血管疾病防治中心,湖北武汉430062

出　　处：《心血管病学进展》2022年第10期915-918,952,共5页Advances in Cardiovascular Diseases

摘　　要：代谢性心血管疾病是包含动脉粥样硬化、2型糖尿病、非酒精性脂肪肝等各类机体代谢性心血管疾病的总称。代谢性心血管疾病是中国居民健康的主要威胁,给社会医疗卫生系统带来了巨大的挑战。近年来,非编码RNA在代谢性心血管疾病的发生发展中越来越受到重视,但其在代谢性心血管疾病中的调控机制仍未阐明。现着重阐明非编码RNA在代谢性心血管疾病中的作用机制,为代谢性心血管疾病的诊断治疗提供新的策略与潜在治疗靶点。Metabolic cardiovascular disease is a general term including atherosclerosis,type 2 diabetes,and non-alcoholic fatty liver disease.Metabolic cardiovascular disease is the main threat to the health of Chinese residents,which has brought great challenges to the social medical and health system.In recent years,non-coding RNA(ncRNA)has been attracted more and more attention in the occurrence and development of metabolic cardiovascular disease,but its regulatory mechanism in metabolic cardiovascular disease has not been clarified.This review will focus on clarifying the mechanism of ncRNA in metabolic cardiovascular disease,and provide new strategies and potential therapeutic targets for the diagnosis and treatment of metabolic cardiovascular disease.

关 键 词：非编码RNA 代谢性心血管疾病 治疗靶点 

分 类 号：R54[医药卫生—心血管疾病]