重症多发性创伤患者Mb、HSP72及PCT水平与预后的关系  

Relationship between Mb,HSP72 and PCT levels and prognosis in patients with severe multiple trauma

作　　者：李景周[1] 陈培莉[1] LI Jingzhou;CHEN Peili(Department of Critical Care Medicine,the First People's Hospital of Shangqiu City,Shangqiu,Henan,China,476100)

机构地区：[1]商丘市第一人民医院重症医学科,河南商丘476100

出　　处：《分子诊断与治疗杂志》2022年第10期1779-1782,共4页Journal of Molecular Diagnostics and Therapy

基　　金：河南省医学科技攻关项目(LHGJ201914613)。

摘　　要：目的 探讨重症多发性创伤患者肌红蛋白(Mb)、热休克蛋白72(HSP72)及降钙素远原(PCT)水平与预后的关系。方法 选取2019年9月至2020年9月商丘市第一人民医院收治的157例重症多发性创伤患者作为观察组,选取同期本院157例健康体检者作为对照组,比较两组Mb、HSP72及PCT。对观察组随访3个月,记录死亡率、生存率。分析不同预后状态的患者Mb、HSP72及PCT水平,绘制受试者工作特征曲线(ROC),评估联合Mb、HSP72及PCT检测对重症多发性创伤患者预后死亡的预测价值。结果 观察组Mb、PCT水平高于对照组,HSP72低于对照组,差异均有统计学意义(P<0.05)。146例患者中,生存108例(73.97%),死亡38例(26.03%)。生存组Mb、PCT低于死亡组,HSP72高于死亡组,差异均有统计学意义(P<0.05)。Mb及PCT异常升高、HSP72异常降低是影响重症多发性创伤患者预后死亡的危险因素(P<0.05)。联合Mb、HSP72及PCT检测预测重症多发性创伤患者预后死亡灵敏度(0.911)、特异度(0.927)、AUC(0.956)均高于单一指标检测(P<0.05)。结论 临床对重症多发性创伤患者行Mb+HSP72+PCT三指标联合检测有助于评估患者预后。Objective To investigate the relationship between the levels of myoglobin(Mb),heat shock protein 72(HSP72)and procalcitonin(PCT)and prognosis in patients with severe multiple trauma.Methods 57 patients with severe multiple trauma admitted to Shangqiu First People ’ s Hospital from September 2019 to September 2020 were selected as the observation group,and 157 healthy physical examination people during the same period were selected as the control group,Mb,HSP72 and PCT between the two groups were compared. The observation group was followed up for 3 months,and the mortality and survival rate were recorded. The levels of Mb,HSP72 and PCT in patients with different prognostic status were analyzed,the receiver operating characteristic curve(ROC)was drawn,and the predictive value of combined Mb,HSP72 and PCT detection on the prognosis and death of severe multiple trauma patients was evaluated.Results The Mb and PCT levels in the observation group were higher than those in the control group,and the HSP72 was lower than that in the control group,and the differences were statistically significant(P<0.05).Among 146 patients,108 survived(73.97%)and 38 died(26.03%). The levels of Mb and PCT in the survival group were lower than those in the death group,and the HSP72 was higher than that in the death group,and the differences were statistically significant(P<0.05). Abnormal increase of Mb and PCT and abnormal decrease of HSP72 were risk factors affecting the prognosis and death of patients with severe multiple trauma(P<0.05). The sensitivity(0.911),specificity(0.927),and AUC(0.956)of combined Mb,HSP72 and PCT detection to predict the prognosis of severe multiple trauma patients were higher than the single indicator detection(P<0.05). Conclusion Clinically,the combined detection of Mb+HSP72+PCT in patients with severe multiple trauma is helpful to assess the prognosis of patients.

关 键 词：重症多发性创伤 MB HSP72 PCT 

分 类 号：R641[医药卫生—外科学]