毒性弥漫性甲状腺肿患者IGF-1、UA及FGF-23与骨密度的关系  

Relationship between IGF-1,UA and FGF-23 and bone mineral density in patients with Graves disease

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作  者:田勇[1] 崔晓磊[1] 侯卫东[1] 李进[1] 丁红霞[1] TIAN Yong;CUI Xiaolei;HOU Weidong;LI Jin;DING Hongxia(Department of Endocrinology and Metabolism,the First People's Hospital of Pingdingshan,Pingdingshan,Henan,China,467000)

机构地区:[1]河南省平顶山市第一人民医院内分泌代谢科,河南平顶山467000

出  处:《分子诊断与治疗杂志》2022年第10期1804-1806,1810,共4页Journal of Molecular Diagnostics and Therapy

基  金:河南省科技厅资助项目(171200211936)。

摘  要:目的 探讨毒性弥漫性甲状腺肿(GD)患者胰岛素样生长因子(IGF-1)、尿酸(UA)及成纤维生长因子23(FGF-23)与骨密度的关系。方法 选取2017年5月至2021年5月在河南省平顶山市第一人民医院进行治疗的98例GD患者作为观察组,选取同期本院102例健康体检者设为对照组,比较两组IGF-1、UA、FGF-23水平及骨密度(BMD)值。根据T值将观察组分为骨量正常组、骨量减少组,比较两组IGF-1、UA及FGF-23水平,分析三项指标与BMD值的相关性。结果 观察组IGF-1、UA及FGF-23水平均高于对照组,BMD值低于对照组,差异均有统计学意义(P<0.05)。观察组根据T值结果分为:骨量正常组(63例)、骨量异常组(35例)。骨量异常组IGF-1、UA及FGF-23水平高于骨量正常组,差异有统计学意义(P<0.05)。Pearson直线相关结果显示,IGF-1、UA及FGF-23水平与BMD值呈负相关(P<0.05)。结论 GD患者伴有不同的IGF-1、UA、FGF-23水平紊乱,IGF-1、UA、FGF-23与GD患者BMD值呈负相关,临床需加强三项指标检测,以预防、治疗GD。Objective To investigate the relationship between insulin-like growth factor(IGF-1),uric acid(UA)and fibroblast growth factor 23(FGF-23)and bone mineral density in patients with Graves(GD).Methods 98 GD patients treated in the First People’s Hospital of Pingdingshan City,Henan Province from May 2017 to May 2021 were selected as the observation group,and 102 healthy people in our hospital during the same period were selected as the control group. IGF-1,UA,FGF-23 levels,and bone mineral density(BMD)values of the two groups were compared. According to T value,the observation group was divided into the normal bone mass group and the osteoporosis group,the levels of IGF-1,UA and FGF-23 in the two groups were compared,and the correlation among the three indicators and BMD value was analyzed.Results The levels of IGF-1,UA and FGF-23 in the observation group were higher than those in the control group,the BMD value in the observation group was lower than that in the control group,and the differences were statistically significant(P<0.05). The observation group was divided into normal bone mass group(63cases)and abnormal bone mass group(35 cases)according to the T value. The levels of IGF-1,UA and FGF-23in the abnormal bone mass group were higher than those in the normal bone mass group,the difference was statistically significant(P<0.05). Pearson linear correlation results showed that IGF-1,UA and FGF-23 levels were negatively correlated with BMD value(P<0.05). Conclusion GD patients are accompanied with different levels of IGF-1,UA,FGF-23 disorders. IGF-1,UA,FGF-23 are negatively correlated with the BMD value of GD. The clinical needs to strengthen the detection of these three indicators to prevent and treat GD.

关 键 词:毒性弥漫性甲状腺肿 IGF-1 UA FGF-23 BMD 

分 类 号:R581.3[医药卫生—内分泌]

 

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