冠心病合并心力衰竭cTnI、Mb、IL-10水平与心功能的相关性  

Correlation between cTnI,Mb,IL-10 levels and cardiac function in patients with coronary heart disease combined with heart failure

作　　者：梁魏昉[1] 李合燕 金培印[1] 聂明 聂绍平[2] LIANG Weifang;LI Heyan;JIN Peiyin;NIE Ming;NIE Shaoping(Department of Cardiovascular Medicine,Anyang People's Hospital,Anyang,Henan,China,455000;Department of Cardiovascular Medicine,Beijing Anzhen Hospital,Beijing,China,100029)

机构地区：[1]安阳市人民医院心血管内科,河南安阳455000 [2]北京安贞医院心内科,北京100029

出　　处：《分子诊断与治疗杂志》2022年第10期1807-1810,共4页Journal of Molecular Diagnostics and Therapy

基　　金：北京市医院管理局“登峰”人才培养计划(DFL20180601)。

摘　　要：目的 分析冠心病合并心力衰竭心肌肌钙蛋白Ⅰ(cTnI)、肌红蛋白(Mb)、白介素-10(IL-10)水平与心功能的相关性。方法 分析2019年6月至2021年3月于安阳市人民医院治疗的125例冠心病患者的临床资料,根据有无合并心力衰竭,将患者分为合并心力衰竭组(n=66)、单纯冠心病组(n=59)。另选取40例同时间段进行健康体检者作为对照组。比较三组c TnI、Mb、IL-10水平、合并心力衰竭组与单纯冠心病组心功能指标,同时分析cTnI、Mb、IL-10水平与心功能指标的相关性。结果 三组cTnI、Mb、IL-10水平:合并心力衰竭组>单纯冠心病组>对照组,差异有统计学意义(P<0.05)。LVEDD、LVESD:合并心力衰竭组>单纯冠心病组>对照组,LVEF:合并心力衰竭组<单纯冠心病组<对照组,差异均有统计学意义(P<0.05)。Spearman相关分析显示,cTnI、Mb、IL-10与LVEDD、LVESD呈负相关(P>0.5),与LVEF呈正相关(P<0.05)。结论 临床可考虑将c TnI、Mb、IL-10水平以及心功能指标作为判断冠心病患者有无合并心力衰竭的参考依据。Objective To analyze the correlation between the levels of cardiac troponin I(c TnI),myoglobin(Mb),interleukin-10(IL-10)and cardiac function in patients with coronary heart disease complicated with heart failure. Methods The clinical data of 125 patients with coronary heart disease treated in Anyang People’s Hospital from June 2019 to March 2021 were analyzed. According to presence or absence of congestive heart failure,the patients were divided into the combined heart failure group(n=66),and the simple coronary heart disease group(n=59). Another 40 patients who underwent physical examination at the same time period were selected as the control group. c TnI,Mb,IL-10 levels,cardiac function indexes of combined heart failure group and simple coronary heart disease group were compared of the parents,and the correlation between the levels of c TnI,Mb,IL-10 and the cardiac function indexes were analyzed. Results The levels of cTnI,Mb,IL-10 in the three groups:combined heart failure group > simple coronary heart disease group > control group,the difference was statistically significant(P<0.05). LVEDD,LVESD:combined heart failure group > simple coronary heart disease group > control group,LVEF:combined heart failure group < simple coronary heart disease group < control group,the differences were statistically significant(P<0.05). Spearman correlation analysis showed that cTnI,Mb,IL-10 were negatively correlated with LVEDD and LVESD(P> 0.5),while were positively correlated with LVEF(P<0.05). Conclusion The levels of cTnI,Mb,IL-10 and cardiac function indicators can be considered as the reference basis for judging whether patients with coronary heart disease have congestive heart failure.

关 键 词：CTNI MB IL-10 冠心病合并心力衰竭 心功能 

分 类 号：R541.6[医药卫生—心血管疾病] R541.4[医药卫生—内科学]