己酮可可碱治疗深静脉血栓后综合征所致慢性下肢静脉性溃疡的临床疗效评价  

Clinical efficacy evaluation of pentoxifylline in the treatment of chronic venous lower extremity ulcers caused by deep vein post-thrombotic syndrome

作　　者：张红松 张磊[1] 张峰[1] 贺新奇[1] 彭军路[1] 刘鹏[1] 何兆鹏 郑丽华[1] 杨艳 Zhang Hongsong;Zhang Lei;Zhang Feng;He Xinqi;Peng Junlu;Liu Peng;He Zhaopeng;Zheng Lihua;Yang Yan(Department of Vascular Surgery,the First Hospital of Hebei Medical University,Shijiazhuang 050011,Hebei,China)

机构地区：[1]河北医科大学第一医院血管外科,河北石家庄050011

出　　处：《血管与腔内血管外科杂志》2022年第9期1030-1033,共4页Journal of Vascular and Endovascular Surgery

基　　金：河北省卫健委青年科技课题(20201145)。

摘　　要：目的探讨己酮可可碱治疗深静脉血栓后综合征(PTS)所致慢性下肢静脉性溃疡的临床疗效。方法选取2016年6月至2020年10月于河北医科大学第一医院就诊的116例深静脉PTS所致慢性下肢静脉性溃疡患者,采用随机数字表法将患者分为对照组(采用标准压力治疗)和试验组(在标准压力治疗的基础上口服己酮可可碱),每组58例。比较两组患者治疗12周后的慢性下肢静脉性溃疡愈合率、PTS严重程度,以及治疗前与治疗12周后的下肢慢性静脉功能不全生活质量问卷(CIVIQ)评分。结果治疗12周后,试验组患者的慢性下肢静脉性溃疡愈合率明显高于对照组患者,重度PTS的发生率明显低于对照组患者,差异均有统计学意义(P<0.01)。治疗12周后,试验组患者的CIVIQ评分明显高于对照组患者,差异有统计学意义(P<0.01)。结论对于深静脉PTS所致慢性下肢静脉性溃疡患者,己酮可可碱联合标准压力治疗可以促进溃疡愈合,降低PTS严重程度,提高患者生活质量,治疗效果优于标准压力治疗。Objective To investigate the clinical efficacy of pentoxifylline in the treatment of chronic venous lower extremity ulcers caused by deep vein post-thrombotic syndrome(PTS).Method A total of 116 patients with chronic venous lower extremity ulcers caused by deep vein PTS who were treated in the First Hospital of Hebei Medical University from June 2016 to October 2020 were selected.The patients were divided into control group(with standard pressure therapy)and experimental group(with oral pentoxifylline based on the standard pressure therapy)by random number table method,with 58 cases in each group.The healing rate of chronic venous lower extremity ulcers,the severity of PTS,and the chronic venous insufficiency quality of life questionnaire(CIVIQ)scores before and after 12 weeks of treatment were compared between the two groups.Result After 12 weeks of treatment,the healing rate of chronic lower extremity venous ulcers in the experimental group was significantly higher than that in the control group,and the incidence rate of severe PTS in the experimental group was significantly lower than that in the control group,and the difference was statistically significant(P<0.01).After 12 weeks of treatment,the CIVIQ scores of the experimental group was significantly higher than that of the control group,and the difference was statistically significant(P<0.01).Conclusion Pentoxifylline combined with standard pressure therapy for patients with chronic venous lower extremity ulcers caused by deep venous PTS could promote ulcer healing,reduce the severity of PTS,and improve patients’quality of life.In all,the therapeutic effect is better than standard pressure therapy.

关 键 词：己酮可可碱 深静脉 血栓后综合征 下肢 静脉性溃疡 临床疗效 生活质量 

分 类 号：R543[医药卫生—心血管疾病]