细化干预措施在多发性大动脉炎患者中的临床应用价值  

Clinical application value of refined intervention measures in patients with multiple takayasu arteritis

作　　者：闫继英 李晶[1] 张春燕[1] 周佳鑫[1] Yan Jiying;Li Jing;Zhang Chunyan;Zhou Jiaxin(Department of Rheumatology and Immunology,Chinese Academy of Medical Science,Peking Union Medical College Hospital,Beijing 100730,China)

机构地区：[1]中国医学科学院北京协和医院风湿免疫科,北京100730

出　　处：《血管与腔内血管外科杂志》2022年第9期1105-1109,共5页Journal of Vascular and Endovascular Surgery

摘　　要：目的探讨细化干预措施在多发性大动脉炎患者中的临床应用价值。方法收集2018年3月至2021年4月中国医学科学院北京协和医院收治的89例多发性大动脉炎患者的临床资料,根据是否接受细化干预措施将患者分为对照组(n=42,给予常规干预)和干预组(n=47,在对照组的基础上采取细化干预措施)。比较两组患者出院后1个月复诊时的Kerr评分和血液检测指标[白细胞计数(WBC)、血红蛋白(Hb)、血小板(PLT)、清蛋白(ALB)、肌酐(Cr)、C反应蛋白(CRP)水平、红细胞沉降率(ESR)、总胆固醇(TC)水平、甘油三酯(TG)水平、丙氨酸转氨酶(ALT)水平]。比较两组患者出院后1个月内的治疗依从性和出院后1个月复诊时的生活质量[36条目健康调查简表(SF-36)评分]。结果出院后1个月复诊时,干预组患者的Kerr评分、PLT、CRP水平、ESR水平均低于对照组患者,差异均有统计学意义(P<0.05);干预组患者出院后1个月复诊时的Cr水平低于对照组患者,但差异无统计学意义(P>0.05)。出院后1个月内,干预组自行停药、自行减药及未记录病情的患者比例均低于对照组患者,差异均有统计学意义(P<0.05)。出院后1个月复诊时,干预组患者SF-36中各维度的评分均高于对照组患者,差异均有统计学意义(P<0.05)。结论细化干预措施可明显改善多发性大动脉炎患者的病情,并提高患者的依从性,改善患者生活质量。Objective To explore the clinical application value of refined intervention measures in patients with multiple takayasu arteritis.Method Clinical data of 89 patients with multiple takayasu arteritis who were admitted in Chinese Academy of Medical Science,Peking Union Medical College Hospital from March 2018 to April 2021 were selected and divided into the control group(n=42,received routine intervention)according to whether they receive detailed intervention measures and intervention group(n=47,received refined intervention on the basis of the control group).The Kerr scores,blood test indexes[white blood cell(WBC),hemoglobin(Hb),platelet(PLT),albumin(ALB),creatinine(Cr),C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),total cholesterol(TC),triglyceride(TG)and alanine aminotransferase(ALT)]at the time of return visit 1 month after discharge were compared.The treatment compliance within 1 month after discharge and the quality of life[scores of 36-item short from health survey(SF-36)]at the time of return visit 1 month after discharge between the two groups were compared.Result At the time of return visit 1 month after discharge,the Kerr scores,PLT,the level of CRP and the level of ESR in the intervention group were lower than those in the control group at the 1-month follow-up visit,and the difference was statistically significant(P<0.05).The Cr level of the patients in the intervention group was lower than that of the patients in the control group at the time of return visit 1 month after discharge,but the difference was not statistically significant(P>0.05).Within 1 month after discharge,the rates of self-discontinuation,self-reduction,and unrecorded illnesses in the intervention group were significantly lower than those in the control group,and the difference was statistically significant(P<0.05).At the time of return visit 1 month after discharge,the dimensional scores of SF-36 in the intervention group were higher than those in the control group,and the difference was statistically significant(P<0.0

关 键 词：多发性大动脉炎 细化干预 炎症指标 病情 生活质量 

分 类 号：R543[医药卫生—心血管疾病]